Cancer stemness, intratumoral heterogeneity, and immune response across cancers
… heterogeneity, possibly by protecting antigenic clones from elimination by the … Regulatory
programs that control the function of stem cells are active in cancer and confer properties that …
programs that control the function of stem cells are active in cancer and confer properties that …
[HTML][HTML] Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
… and reduced sensitivity to vaccine-elicited antibodies 9 , and for which … and quality of immune
responses may be suboptimal. … (quantity) and/or lower-affinity antibodies (quality) resulting …
responses may be suboptimal. … (quantity) and/or lower-affinity antibodies (quality) resulting …
[HTML][HTML] Treg heterogeneity, function, and homeostasis
D Shevyrev, V Tereshchenko - Frontiers in immunology, 2020 - frontiersin.org
… homeostasis and antigen-specific immune response regulation. … Thus, the migration properties
of T-regulatory cells are … Treg pool is a function of the number of effectors capable of IL-2 …
of T-regulatory cells are … Treg pool is a function of the number of effectors capable of IL-2 …
Tumor heterogeneity correlates with less immune response and worse survival in breast cancer patients
KA McDonald, T Kawaguchi, Q Qi, X Peng… - Annals of surgical …, 2019 - Springer
… characteristics coexist within the same tumor.1,2 Tumor … higher fractions of immunosuppressive
regulatory T cells (Tregs; p ≤ … the antibodies against those antigens,3 our result does not …
regulatory T cells (Tregs; p ≤ … the antibodies against those antigens,3 our result does not …
[HTML][HTML] Constitutive immune mechanisms: mediators of host defence and immune regulation
… innate immune system and antigen-specific receptors of the adaptive … function through a
broad and heterogeneous set of mechanisms, the constitutive immune responses all function as …
broad and heterogeneous set of mechanisms, the constitutive immune responses all function as …
Intratumoral heterogeneity in cancer progression and response to immunotherapy
… immune cell states as a major factor in the regulation of anticancer immune responses. …
limited (although heterogeneous) reactivity against tumor-derived antigens, suggesting that their …
limited (although heterogeneous) reactivity against tumor-derived antigens, suggesting that their …
A guide to antigen processing and presentation
… immune responses require the involvement of the antigen … Members of the CD1 family
present a heterogeneous set of … -DM is regulated by HLA-DO, but the mechanism of regulation …
present a heterogeneous set of … -DM is regulated by HLA-DO, but the mechanism of regulation …
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
… New techniques have highlighted the enormous heterogeneity of leukocyte subsets in the …
, in part through regulation of T cell activation and adaptive immune responses, in an antigen-…
, in part through regulation of T cell activation and adaptive immune responses, in an antigen-…
Epigenetic regulation of the innate immune response to infection
Q Zhang, X Cao - Nature Reviews Immunology, 2019 - nature.com
… its binding partner heterogeneous nuclear ribonucleoprotein L, … These studies raise a number
of exciting implications about … (KSHV) latency-associated nuclear antigen (LANA) directly …
of exciting implications about … (KSHV) latency-associated nuclear antigen (LANA) directly …
T follicular helper cell heterogeneity: time, space, and function
… humoral arm of adaptive immune responses. Mature Tfh cells … generate protective and
regulatory IgA antibodies. Because … of Tfh cell heterogeneity reveal the dynamic nature of this cell …
regulatory IgA antibodies. Because … of Tfh cell heterogeneity reveal the dynamic nature of this cell …