… proteins remain very promiscuous for peptide binding as … structure of peptides for binding
to MHC class II molecules. The … females of this mutant mouse line developed diabetes, and no …

… the early pre-diabetic phase of disease in mice. A single cell … proteins remain very
promiscuous for peptide binding as … are tightly associated to non-Aspβ57 MHC class II molecules. …

… Due to the use of mouse models in this thesis, the study has … , as well as being a weak
peptide binder 144,145. Thus, … -peptide:IAg7 CAR Tconvs could kill the islet-peptide presenting …

… immune receptor antigenic responses and MHC-associated peptide proteomics. In parallel,
… of the MHC class I (Laimer and Lackner 2021, Wu et al. 2021). This promiscuity poses a …

… epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies … is relatively promiscuous,
and the binding groove is open at … therapy for T1D, and other related autoimmune conditions. …

… C-peptide fragment covalently bound to the WE14 peptide, a … The peptide-binding grooves
of MHC class II molecules can be … of the nonobese diabetic mouse class II Ia beta chain is …

… + T cells are activated by fusion peptides bound to MHC class II molecules not only in NOD
… mAbs targeting peptide-MHC class II complexes ameliorated mouse autoimmune disorders …

… peptide-major histocompatibility complex class II (… type 1 diabetes (T1D)-relevant pMHCII-NP
types that display an epitope from the insulin B-chain bound to the same MHCII molecule (…

… , or to bind peptides, as measured relative to iYAg7Гs closely related MHC class ii molecule,
… Figure 10: The in vivo substitution of an aspartic acid for serine β57 of I Ag7 modifies the …

… NOD mouse model, in which MHC class I … bound peptides, enhancing peptide-MHC class
II binding. A similar binding property has been found in the human MHC class II genotype HLA …