… 1 2 and loss-of-function genetic variants in IL23R confer protection from IBD.3 As such, the
… immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans. …

… -of-function genetic variants in IL23R confer protection from … in therapeutic trials for
immune-mediated diseases, 9 we … ATG16L1 loss-of-function variants impair bacterial clearance, …

… also detected additional variants in the IL23R gene, and in … IL-12) were protected from
disease in several experimental … STAT4 activation and IL-23-induced STAT3 phosphorylation …

… As an example, IL-23p19-deficient (Il23a–/–) mice were protected against the development …
to impaired production of IL-17 [58–60]. Of interest, the IL23R R381Q gene variant leads to …

… from donors who expressed the protective R381Q IL-23R … results in other immune-mediated
inflammatory disorders, as … -23 p19-specific IgG significantly suppresses IL-23-induced IL-17 …

… shown to exacerbate chronic immune-mediated inflammation. Well-… The specific role of
IL-17 in protection against the fungus … in the IL-23R as a strong protective genetic factor (112). …

… to various experimental immune-mediated diseases, such as … protective IL23R variants, such
as G149R, V362I and R381Q, … controls showed that ex vivo IL-23-induced IL-17 expression …

… The IL23R R381Q gene variant protects against immune-mediated diseases by
impairing IL-23-induced Th17 effector response in humans. PLoS One 2011;6:e17160. …

… Psoriasis is an immune-mediated proliferative skin disorder … , Arg381Gln, R381Q) in the IL-23
receptor (IL23R) gene in control … effects by attenuation of IL-23-induced TH17 functions (IL-…

… immune-mediated diseases, including Crohn’s disease and ulcerative colitis. … The IL23R
R381Q protective variant results in a loss-of-… to protection from development of Crohn’s disease. …