Bacteria and bacterial derivatives as drug carriers for cancer therapy

Z Cao, J Liu - Journal of controlled release, 2020 - Elsevier
… We also discuss the advantages as well as the limitations of these tumor-targeting … in the
development of bacteria and their outer membrane vesicles as drug carriers for cancer therapy. …

Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging

V Gujrati, J Prakash, J Malekzadeh-Najafabadi… - Nature …, 2019 - nature.com
… enabled the use of bacterial outer membrane vesicles (OMVs) to … bacterial membrane.
Future work should verify and extend our findings by checking for systemic toxicity or toxic effects

Self‐blockade of PD‐L1 with bacteria‐derived outer‐membrane vesicle for enhanced cancer immunotherapy

J Pan, X Li, B Shao, F Xu, X Huang, X Guo… - Advanced …, 2022 - Wiley Online Library
… The therapeutic effects were studied using the CT26 model. The tumor inhibition rate of
LOMV@PD-1 reached ≈70%, which was only 44% in the anti-PD-L1+LOMV group (Figure S14a…

The tremendous biomedical potential of bacterial extracellular vesicles

J Xie, Q Li, F Haesebrouck, L Van Hoecke… - Trends in …, 2022 - cell.com
bacteria, known as cytoplasmic membrane vesicles (CMVs), are derived from the cytoplasmic
membrane, … Prophage-triggered membrane vesicle formation through peptidoglycan …

Detection of bacterial membrane vesicles by NOD-like receptors

EL Johnston, B Heras, TA Kufer… - International Journal of …, 2021 - mdpi.com
… are called outer membrane vesicles (OMVs), whereas BMVs produced by … bacteria are
released from the cellular membrane of the bacterium and are referred to as membrane vesicles (…

Human neutrophil membrane-derived nanovesicles as a drug delivery platform for improved therapy of infectious diseases

J Gao, X Dong, Y Su, Z Wang - Acta biomaterialia, 2021 - Elsevier
… In a mouse model of bacterium-induced peritonitis, we … -loaded vesicles and artificial cell
membrane vesicles. We … pathways and pathogens may benefit the therapy of peritonitis. Our …

Host-and microbiota-derived extracellular vesicles, immune function, and disease development

L Macia, R Nanan, E Hosseini-Beheshti… - International journal of …, 2019 - mdpi.com
… or as membrane vesicles when released by Gram-positive bacteria. Bacteria derived EVs
can affect host immunity with pathogenic bacteria derived EVs having pro-inflammatory effects

Bioengineering bacterial vesicle-coated polymeric nanomedicine for enhanced cancer immunotherapy and metastasis prevention

Q Chen, H Bai, W Wu, G Huang, Y Li, M Wu, G Tang… - Nano …, 2019 - ACS Publications
… We herein propose a bioengineering approach where bacterial outer membrane vesicles
(OMVs) … (a) Illustration of the therapeutic scheme for validating the protective effects of ORFT …

[HTML][HTML] Extracellular vesicles: An emerging platform in gram-positive bacteria

S Bose, S Aggarwal, DV Singh, N Acharya - Microbial Cell, 2020 - ncbi.nlm.nih.gov
… Extracellular vesicles (EV), also known as membrane vesicles, … bacteria. Several reports
suggest that archaea, gram-negative bacteria, and eukaryotic cells secrete membrane vesicles

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

K Cheng, R Zhao, Y Li, Y Qi, Y Wang, Y Zhang… - Nature …, 2021 - nature.com
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed.
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …