… the cytosol and mitochondria, respectively 23,36 . In cMPC1 −/− hearts, the lactate:pyruvate
ratio … 3h,i), which suggests that the redox state was maintained in mitochondria, but not in the …

… higher [nicotinamide adenine dinucleotide (NADH)]/[oxidized form of … Lactate metabolizes
to pyruvate via the lactate … shuttling, reducing equivalents from the cytosol to the mitochondria. …

… Effect of perinatal asphyxia on tuberomammillary nucleus … Furthermore, lactate and protons
accumulate as the result of … β-Nicotinamide adenine dinucleotide 2-phosphate reduced …

… important redox pair is nicotinamide adenine dinucleotide (… redox pairs, typically lactate
and pyruvate in the cytosol, and β… C]pyruvate allow detection of the redox response in cytosol …

… Therefore, the heart muscle can oxidize lactate and use the resulting … in the cytosol.
Consistently, the K M of LDH-5 for lactate, ie, for the reverse reaction from lactate to pyruvate, is …

… Abstract: The nicotinamide adenine dinucleotide phosphate (NADP… ) and subsequently
oxidized to pyruvate by ME1, while NADPH is … , such as within mitochondria and cytoplasm [85]. …

… Nicotinamide adenine dinucleotide plays a dual role as a … the fermentation of pyruvate to
produce lactate in mammalian … In the cytosol, NADP + is reduced to NADPH by the glucose-6-…

… ) above which they halt, measurement of ΔGATP would be a … 13C]pyruvate, in which regional
variations of PDH flux in the … In the healthy heart cell membrane depolarisation during the …

… Lactate and pyruvate together serve as a circulating redox … may buffer their NAD and NADH
pools with the cytosol 45 . … and heart showed a decreased NADH-to-NAD ratio 46 . Thus, …

… inhibits LDH-A to decline the pyruvate reduction to lactate. … pyruvate preserved the nicotinamide
adenine dinucleotide … of oxygen and energy, enhancing NAD + levels in the cytosol on …