MHY2245, a sirtuin inhibitor, induces cell cycle arrest and apoptosis in HCT116 human colorectal cancer cells
YJ Kang, JY Jang, YH Kwon, JH Lee, S Lee… - International Journal of …, 2022 - mdpi.com
… Sirtinol also induces apoptosis in lung cancer … apoptosis [27,31]. Therefore, in the present
study, we evaluated the cytotoxic effect of MHY2245, a sirtinol derivative, on SIRT1/2 inhibition …
study, we evaluated the cytotoxic effect of MHY2245, a sirtinol derivative, on SIRT1/2 inhibition …
[HTML][HTML] Sirtuin modulators in cellular and animal models of human diseases
… amide structure of sirtinol and shows mild SIRT1 and SIRT2 … SIRT1-3 inhibitor, portrayed
strong antiproliferative effects in … -116 colorectal, and NCI-H23 lung cancer cells. However, JH-…
strong antiproliferative effects in … -116 colorectal, and NCI-H23 lung cancer cells. However, JH-…
[HTML][HTML] Prostaglandin 15d-PGJ2 inhibits proliferation of lung adenocarcinoma cells by inducing ROS production and activation of apoptosis via sirtuin-1
J Slanovc, M Mikulčić, N Jahn, NGT Wizsy… - … et Biophysica Acta (BBA …, 2024 - Elsevier
… We show that SIRT1 modulates the effects of 15d-PGJ 2 and may be used … human lung
adenocarcinoma cell lines were used. All three cell lines were derived from non-small cell lung …
adenocarcinoma cell lines were used. All three cell lines were derived from non-small cell lung …
The sirtuin family in cancer
LF Costa-Machado, PJ Fernandez-Marcos - Cell Cycle, 2019 - Taylor & Francis
… In the lung, high SIRT1 expression has … sirtuin inhibitors described with different selectivity
for SIRT1, SIRT2, SIRT3, SIRT5, and SIRT6. One of the first inhibitors described was Sirtinol, a …
for SIRT1, SIRT2, SIRT3, SIRT5, and SIRT6. One of the first inhibitors described was Sirtinol, a …
Sirtuin modulators: past, present, and future perspectives
F Fiorentino, N Mautone, M Menna… - Future Medicinal …, 2022 - Future Science
… absence of effect on the acetylation status of the SIRT1 substrates H3K9 … sirtinol, initially
identified as SIRT1/2 inhibitor. 4a inhibits … Both 7b and 7c showed antiproliferative effects in lung …
identified as SIRT1/2 inhibitor. 4a inhibits … Both 7b and 7c showed antiproliferative effects in lung …
[HTML][HTML] Evaluating the iron chelator function of sirtinol in non-small cell lung cancer
MS Petronek, K Bayanbold, K Amegble… - Frontiers in …, 2023 - frontiersin.org
… non-small cell lung cancer (NSCLC). Sirtinol, a sirtuin (SIRT) 1 and 2 specific inhibitor, is a
… Thus, sirtuins 1 and 2 represent valuable targets for cancer therapy. Recent studies show …
… Thus, sirtuins 1 and 2 represent valuable targets for cancer therapy. Recent studies show …
Sirtuins as important factors in pathological states and the role of their molecular activity modulators
EM Kratz, K Sołkiewicz, A Kubis-Kubiak… - International journal of …, 2021 - mdpi.com
… ] have analyzed the effects of sirtuin inhibition using sirtinol (a non-specific sirtuin inhibitor) on
… In cigarette smoke extract (CSE)-treated human pulmonary microvascular endothelial cells …
… In cigarette smoke extract (CSE)-treated human pulmonary microvascular endothelial cells …
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
… active as micromolar SIRT1/2 inhibitors [IC 50 (SIRT1) = 9.8 µM; IC 50 (SIRT2) = 12.3 µM],
that displays significant antiproliferative and pro-apoptotic properties in several cancer cell …
that displays significant antiproliferative and pro-apoptotic properties in several cancer cell …
Versatile role of sirtuins in metabolic disorders: from modulation of mitochondrial function to therapeutic interventions
… induced when SIRT1 is inhibited by expression of dominant-negative SIRT1 or sirtinol and
… , NFATc2 or HIF1α in both human and murine pulmonary artery smooth muscle cells that are …
… , NFATc2 or HIF1α in both human and murine pulmonary artery smooth muscle cells that are …
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
… The Sirtuin family, which is widely distributed throughout the nature, has been divided into
seven human isoforms (Sirt1-… of Sirtuins, which is expected to be beneficial to relevant studies. …
seven human isoforms (Sirt1-… of Sirtuins, which is expected to be beneficial to relevant studies. …