Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases

S Demine, P Renard, T Arnould - Cells, 2019 - mdpi.com
uncoupling properties are discussed. Second, we summarize the most recent findings linking
mitochondrial uncoupling and other cellular or biological … production, protein secretion, cell …

[HTML][HTML] Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response

P Barreto, RM Counago, P Arruda - Mitochondrion, 2020 - Elsevier
… the mitochondrial inner membrane from ATP production. The protein was named mitochondrial
uncoupling protein … , transports protons back to the mitochondrial matrix, generating heat. …

[HTML][HTML] Mitochondrial proton leaks and uncoupling proteins

DG Nicholls - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2021 - Elsevier
… proton conductance is found in all mitochondria, independent of any uncoupling protein [49].
In any functional investigation of uncoupling protein-mediated proton conductance this …

Uncoupling proteins in the mitochondrial defense against oxidative stress

DT Hass, CJ Barnstable - Progress in retinal and eye research, 2021 - Elsevier
mitochondrial ROS production, and this gradient can be modulated by members of the
mitochondrial uncoupling protein … has been shown to uncouple oxidative phosphorylation, with …

Mitochondrial uncoupling and longevity–A role for mitokines?

S Klaus, M Ost - Experimental gerontology, 2020 - Elsevier
… is an intrinsic property of all mitochondria and according to the “uncoupling to survive” …
uncoupling protein (UCP1) mediated, as well as experimentally induced mitochondrial uncoupling

Protective role of mitochondrial uncoupling proteins against age-related oxidative stress in type 2 diabetes mellitus

M Čater, LK Bombek - Antioxidants, 2022 - mdpi.com
… in mice, rats, and humans have shown that mitochondrial uncoupling proteins (UCPs)
have important protective effects against oxidative stress and mitochondrial dysfunction [44,45,46]. …

Neuroprotective potential of mild uncoupling in mitochondria. Pros and cons

DB Zorov, NV Andrianova, VA Babenko, IB Pevzner… - Brain Sciences, 2021 - mdpi.com
… in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of …
mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. …

[HTML][HTML] Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)

P Ježek, M Jabůrek, RK Porter - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
… for the maximal uncoupling range for UCP2 in lung mitochondria were 12.5 mV [37,… uncouples
reflects the relative abundance of UCP2. In conclusion, the amount of uncoupling protein

The uncoupling of respiration in plant mitochondria: keeping reactive oxygen and nitrogen species under control

VN Popov, MY Syromyatnikov, AR Fernie… - Journal of …, 2021 - academic.oup.com
… Recent findings suggest that uncoupled respiration is … and possible functions of uncoupled
mitochondrial respiration in … (AOX), and the uncoupling protein (UCP) are examined in …

Structural basis of purine nucleotide inhibition of human uncoupling protein 1

SA Jones, P Gogoi, JJ Ruprecht, MS King, Y Lee… - Science …, 2023 - science.org
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its
specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, …