… In vitro and in vivo studies have demonstrated the high efficacy of BBR3464 in cisplatin
sensitive and resistant tumors, as well as in cells with a mutation of the p53 oncosuppressive …

… However, clinical studies have proved that the efficacy of … class, BBR3464 is a trinuclear
platinum(II) complex which … and A549 cell lines than cisplatin. Another monofunctional …

… of the platinum compound, since deactivation of cisplatin and BBR3464 by binding to … 2)
and the results show that the trinuclear complexes have the lowest values. We observed …

… Chemical structures of trinuclear platinum agents. The … complexes are patterned like
those of cisplatin ie they are of … the trinuclear BBR3464 and its dinuclear analogues namely: …

… 1) is a trinuclear platinum compound having two … BBR 3464 is effective against cell lines
showing cisplatin … It has demonstrated anti-cancer efficacy comparable to cisplatin and …

… Additionally, BBR 3464 was shown to be more active than cisplatin in p53 mutant tumors. …
the increased efficiency of BBR 3464 compared to therapeutic combinations of platinum …

… , all these platinum analogs were not so efficacious except … due to cisplatin and carboplatin
in many human cancer cell lines. … In a study, tri-nuclear complex such as BBR 3464 (41) was …

… We have selected a trinuclear PtAu2 compound containing the … DNA-cisplatin-HMG1 complex
and B) DNA-cisplatin adducts’ cell … BBR3464 was the first trinuclear platinum(II) to undergo …

… , Cisplatin provided the first evidence that Platinum interacts … is an unusual trinuclear
platinum complex with an overall … , MA, Phase II study of BBR 3464 as treatment in patients with …

… with both BBR3464 and cisplatin [78]. These properties contribute for enhanced efficacy of
such … recrystallized in a mononuclear platinum(II) complex [PtCl 2 (DMSO)(Schiff base)]. This …