Selected platinum complexes in standard and modern anti-cancer therapies
A Kopacz-Bednarska, T Król - Biuletyn Polskiego …, 2022 - journals.viamedica.pl
… In vitro and in vivo studies have demonstrated the high efficacy of BBR3464 in cisplatin
sensitive and resistant tumors, as well as in cells with a mutation of the p53 oncosuppressive …
sensitive and resistant tumors, as well as in cells with a mutation of the p53 oncosuppressive …
A novel star-shaped trinuclear platinum (II) complex based on a 1, 3, 5-triazine core displaying potent antiproliferative activity against TNBC by the mitochondrial injury …
Y Wu, D Zhao, J Shang, W Huang, Z Chen - Dalton Transactions, 2022 - pubs.rsc.org
… However, clinical studies have proved that the efficacy of … class, BBR3464 is a trinuclear
platinum(II) complex which … and A549 cell lines than cisplatin. Another monofunctional …
platinum(II) complex which … and A549 cell lines than cisplatin. Another monofunctional …
Molecular dynamics simulation of non-covalent interactions between polynuclear platinum (II) complexes and DNA
… of the platinum compound, since deactivation of cisplatin and BBR3464 by binding to … 2)
and the results show that the trinuclear complexes have the lowest values. We observed …
and the results show that the trinuclear complexes have the lowest values. We observed …
[PDF][PDF] Towards the development of alternative platinum-based anticancer drugs: a kinetic and mechanistic study of mono and dinuclear trans-platinum (II) complexes.
MA Olusegun - 2019 - core.ac.uk
… Chemical structures of trinuclear platinum agents. The … complexes are patterned like
those of cisplatin ie they are of … the trinuclear BBR3464 and its dinuclear analogues namely: …
those of cisplatin ie they are of … the trinuclear BBR3464 and its dinuclear analogues namely: …
[PDF][PDF] Metal-Based Drugs in Cancer Therapy
S Nath, A Datta, A Das, S Adhikari - Int. J. Exp. Res. Rev, 2024 - researchgate.net
… 1) is a trinuclear platinum compound having two … BBR 3464 is effective against cell lines
showing cisplatin … It has demonstrated anti-cancer efficacy comparable to cisplatin and …
showing cisplatin … It has demonstrated anti-cancer efficacy comparable to cisplatin and …
Metallo-drugs in cancer therapy: Past, present and future
… Additionally, BBR 3464 was shown to be more active than cisplatin in p53 mutant tumors. …
the increased efficiency of BBR 3464 compared to therapeutic combinations of platinum …
the increased efficiency of BBR 3464 compared to therapeutic combinations of platinum …
Advancements in the use of platinum complexes as anticancer agents
… , all these platinum analogs were not so efficacious except … due to cisplatin and carboplatin
in many human cancer cell lines. … In a study, tri-nuclear complex such as BBR 3464 (41) was …
in many human cancer cell lines. … In a study, tri-nuclear complex such as BBR 3464 (41) was …
Development of Platinum (IV)-Gold (I)-Based Anticancer Agents
JE López-Hernández - 2024 - search.proquest.com
… We have selected a trinuclear PtAu2 compound containing the … DNA-cisplatin-HMG1 complex
and B) DNA-cisplatin adducts’ cell … BBR3464 was the first trinuclear platinum(II) to undergo …
and B) DNA-cisplatin adducts’ cell … BBR3464 was the first trinuclear platinum(II) to undergo …
Role of metallodrugs in medicinal inorganic chemistry
… , Cisplatin provided the first evidence that Platinum interacts … is an unusual trinuclear
platinum complex with an overall … , MA, Phase II study of BBR 3464 as treatment in patients with …
platinum complex with an overall … , MA, Phase II study of BBR 3464 as treatment in patients with …
Synthesis and Development of Platinum-Based Anticancer Drugs
PP Phadnis - Handbook on Synthesis Strategies for Advanced …, 2021 - Springer
… with both BBR3464 and cisplatin [78]. These properties contribute for enhanced efficacy of
such … recrystallized in a mononuclear platinum(II) complex [PtCl 2 (DMSO)(Schiff base)]. This …
such … recrystallized in a mononuclear platinum(II) complex [PtCl 2 (DMSO)(Schiff base)]. This …