[HTML][HTML] Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/β-catenin and Jak2/Stat3 pathways

Y Zhang, L Zhang, X Fan, W Yang, B Yu, J Kou… - Biomedicine & …, 2019 - Elsevier
… This study reveals another mechanism of captopril on heart failure caused by pressure … In
conclusion, Cap showed a protective effect on TAC-induced cardiac apoptosis, which could be …

Angiotensin-converting enzyme inhibitors

R Ferrari, G Guardigli, B Bozkurt - The ESC Textbook of Heart …, 2023 - books.google.com
… the combination of low blood pressure, increased potassium level, … shared also by the rival
of captopril: Merck's longer-acting ACE … of blood volume and peripheral vascular resistance. …

Hypotensive effect of captopril on deoxycorticosterone acetate-salt-induced hypertensive rat is associated with gut microbiota alteration

H Wu, TYC Lam, TF Shum, TY Tsai, J Chiou - Hypertension Research, 2022 - nature.com
… to elucidate the blood pressure-lowering effect of captopril on … Hypertension was induced for
14 weeks by subcutaneous injection … the central and peripheral nervous systems [42]. Since …

ACE-Inhibitors in Hypertension: A historical perspective and current insights

S Cutrell, IS Alhomoud, A Mehta, AH Talasaz… - Current Hypertension …, 2023 - Springer
… and promoting deleterious effects on blood pressure. Parts of … After years of research and
development, captopril, the first … mortality, combined CHD, peripheral arterial disease, cancer, …

[PDF][PDF] Toxin to medicine and bioisosterism in drug development: a study of the discovery and development of ACE inhibitors from snake venom

AR Oladipupo - Macedonian Pharmaceutical Bulletin, 2020 - bulletin.mfd.org.mk
… High blood pressure or hypertension, defined as blood pressureSQ 14,225 was found to
be the most potent inhibitor of all the compounds tested and Squibb introduced it as captopril (…

[HTML][HTML] Mechanisms for the development of heart failure and improvement of cardiac function by angiotensin-converting enzyme inhibitors

SK Bhullar, AK Shah, NS Dhalla - Scripta Medica, 2022 - scindeks.ceon.rs
effects for regulating the peripheral blood flow and blood … in cardiac output and fall in blood
pressure which result in the … beneficial effects of some of these agents including captopril, …

Angiotensin-converting enzyme

F Arrighi, E Berrino, D Secci - Metalloenzymes, 2024 - Elsevier
… a pivotal role in the blood pressure (BP) regulation trough the … from the peripheral one,
ensured also by the blood-brain … zinc-chelating ability, produced captopril (SQ 14225), the first …

Hypothalamic paraventricular nucleus augments baroreflex sensitivity, role of angiotensin II

B Rostami, A Nasimi, M Hatam - Brain Research, 2023 - Elsevier
… In support of our finding, it has been demonstrated that increasing arterial pressure using
Phe (iv), produced an increase in firing rate and reducing arterial pressure by hydralazine (iv) …

Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring

HB Li, ML Xu, WJ Xia, YY Dong, B Peng, Q Su… - Toxicology and Applied …, 2024 - Elsevier
… a central area (50 × 50 cm) and a peripheral area (25 cm on each side). Animals were gently
placed in the center of … Captopril can reduce the blood pressure of the object and, under the …

Prescribed Systemic Drugs and Intraocular Pressure

J Zhang, PA Netland - Glaucoma Medical Therapy: Principles …, 2020 - books.google.com
… no demonstrable effect on the heart rate or blood pressure. 21 … by both central and peripheral
adrenergic mechanisms. 27, … Effect of oral captopril (SQ 14225) on intraocular pressure in …