… MRI studies using motor paradigms have consistently demonstrated an activation shift from
the primary motor … forms of the disease, or upper motor neuron predominant phenotypes …

… adult onset motor neuron disease with no effective disease … describing unifying disease-associated
signatures, imaging … , by attenuating signals from moving structures so that it does not …

… From a therapeutic perspective, there is a marked shift from the notion of ‘… In contrast, academic
studies have consistently … Most descriptive studies compare a specific MND phenotype to …

… imaging studies are superior to cross-sectional studies as … such as the Telehealth in Motor
Neuron disease (TiM) system … traveling long distances for research appointments (249). Once …

… physiological roles, existing imaging studies in motor neuron diseases typically evaluate
the … We have focused on descriptive analyses and not explored direct clinico-radiological …

… Primary motor neuronopathies are characterized by progressive degenerative loss of …
motoneurons (lower motor neurons) or loss of giant pyramidal Betz cells (upper motor neurons). …

… cortical abnormalities (magnetic resonance imaging, MRI) whereas single-photon emission
… kanji errors on a written description task. Bilateral frontotemporal atrophy (MRI) and hypo-…

… the load of motor neuron disease is rapidly moving toward 400 … including specific
electromyography and MRI; (3) specialized … depending on lifestyle or environment because they …

… These descriptive themes detailed patients’ and carers’ experiences of living with … to ‘go
beyond’ the content of the original papers 17 and develop the thematic synthesis, the descriptive …

… ) research has undergone a major expansion in its landscape… Some years after the initial
description of TDP43 as the … motor neurons and fibroblasts from patients with ALS 83,85 . …