[HTML][HTML] The mysteries of capsaicin-sensitive afferents
… only to capsaicin but a variety of unrelated stimuli including … potential cation channel,
subfamily V member 1), was cloned … , the capsaicin receptor turned out to be a transient receptor …
subfamily V member 1), was cloned … , the capsaicin receptor turned out to be a transient receptor …
The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach
DC Rosenberger, U Binzen, RD Treede… - Journal of Translational …, 2020 - Springer
… tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by …
c Schematic view of integrated laser stimulation set-up for cell physiology experiments. The …
c Schematic view of integrated laser stimulation set-up for cell physiology experiments. The …
A single TRPV1 amino acid controls species sensitivity to capsaicin
Y Chu, BE Cohen, H Chuang - Scientific reports, 2020 - nature.com
… for studying environmental stimuli of TRPV1 is capsaicin, a … TRPV1 channels cloned from
different species share a … Acid potentiation of the capsaicin receptor determined by a key …
different species share a … Acid potentiation of the capsaicin receptor determined by a key …
FXYD6 promotes thermal nociception by regulating TRPV1
H Luo, B Cai, J Pan, HX Shi, KK Wang… - Molecular …, 2021 - journals.sagepub.com
… in these sensory neurons impaired the behavioral responses to noxious heat stimulus and
intraplantar injection of capsaicin. The capsaicin-induced and TRPV1-mediated currents were …
intraplantar injection of capsaicin. The capsaicin-induced and TRPV1-mediated currents were …
Capsaicin: Physicochemical properties, cutaneous reactions and potential applications in painful and inflammatory conditions
… The capsaicin receptor is highly expressed in the … heat and mechanical stimulation,
capsaicin exerting a greater … chemical structure and pain-producing potency of pungent …
capsaicin exerting a greater … chemical structure and pain-producing potency of pungent …
It takes two vanilloid ligand bindings per channel to transduce painful capsaicin stimuli
TY Liu, Y Chu, HR Mei, DS Chang, HH Chuang - bioRxiv, 2019 - biorxiv.org
… The capsaicin receptor TRPV1 in mammals evolved the capability of integrating pain arising
… Partial agonist anandamide (AEA) was non-pain-producing. Even administering AEA at its …
… Partial agonist anandamide (AEA) was non-pain-producing. Even administering AEA at its …
[HTML][HTML] Two vanilloid ligand bindings per channel are required to transduce capsaicin-activating stimuli
TY Liu, Y Chu, HR Mei, D Chang… - Frontiers in Molecular …, 2020 - frontiersin.org
… The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals
has evolved the capability to integrate pain signal arising from harmful temperature and …
has evolved the capability to integrate pain signal arising from harmful temperature and …
TRPV1-targeted drugs in development for human pain conditions
… to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including heat, low pH or
… that TRPV1 was identified and cloned [8]. The capsaicin receptor TRPV1 is the prototypical …
… that TRPV1 was identified and cloned [8]. The capsaicin receptor TRPV1 is the prototypical …
A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
M Nikolaeva-Koleva, L Butron… - Scientific Reports, 2021 - nature.com
… receptor potential (TRP) family, is a nonselective calcium permeable ion channel gated by
physical and chemical stimuli… We next analyzed the effect of AG1529 on the capsaicin potency …
physical and chemical stimuli… We next analyzed the effect of AG1529 on the capsaicin potency …
The industrial solvent 1, 4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1
X Mo, Q Liu, L Gao, C Xie, X Wei, P Pang, Q Tian… - BMC biology, 2022 - Springer
… TRPV1 is a multimodal channel and can be activated by various stimuli such as voltage,
heat, protons, capsaicin, and the pharmacological compound 2-aminoethoxydiphenyl borate (2-…
heat, protons, capsaicin, and the pharmacological compound 2-aminoethoxydiphenyl borate (2-…