Surfactant replacement therapy: from biological basis to current clinical practice
R Hentschel, K Bohlin, A van Kaam, H Fuchs… - Pediatric …, 2020 - nature.com
… This review summarizes the current knowledge on the physiological action of endogenous
and exogenous pulmonary surfactant, the role of different types of animal-derived and …
and exogenous pulmonary surfactant, the role of different types of animal-derived and …
Pulmonary surfactant: a unique biomaterial with life-saving therapeutic applications
B Pioselli, F Salomone, G Mazzola… - Current Medicinal …, 2022 - ingentaconnect.com
… surfactants and its translation to clinical surfactant therapies. Indeed, the amalgamation of
biophysical knowledge and physiological behaviour of lung surfactant … to lung formation and …
biophysical knowledge and physiological behaviour of lung surfactant … to lung formation and …
[HTML][HTML] A recipe for a good clinical pulmonary surfactant
J Pérez-Gil - biomedical journal, 2022 - Elsevier
… current concepts on the compositional and structural determinants defining pulmonary
surfactant … -derived or recombinant or synthetic therapeutic surfactants, as well as a the most …
surfactant … -derived or recombinant or synthetic therapeutic surfactants, as well as a the most …
[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges
JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
… Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic …
stabilizes the respiratory air-liquid interface in the mammalian lung. The present review dissects …
stabilizes the respiratory air-liquid interface in the mammalian lung. The present review dissects …
New insights into exogenous surfactant as a carrier of pulmonary therapeutics
B Baer, LMP Souza, AS Pimentel… - Biochemical …, 2019 - Elsevier
… Similarly, molecular dynamics simulations of clarithromycin interacting with a lung surfactant
model provide evidence that clarithromycin may be incorporated into the lung surfactant …
model provide evidence that clarithromycin may be incorporated into the lung surfactant …
The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles
… compromise the respiratory function. This review explains the key role of pulmonary surfactant
to … with surfactant and unravelling the mutual effects. The implication of the nanoparticle-…
to … with surfactant and unravelling the mutual effects. The implication of the nanoparticle-…
Recent progress on surfactant protein A: cellular function in lung and kidney disease development
SD King, SY Chen - American Journal of Physiology-Cell …, 2020 - journals.physiology.org
… In this mini-review, we discuss SP-A functions and the consequences of SP-A genetic
mutations or pulmonary surfactant deficiencies, with a specific emphasis on the recent progress in …
mutations or pulmonary surfactant deficiencies, with a specific emphasis on the recent progress in …
Synthetic surfactants with SP‐B and SP‐C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases
J Johansson, T Curstedt - Journal of internal medicine, 2019 - Wiley Online Library
… Respiratory distress syndrome (RDS), which depends on insufficient amounts of pulmonary
surfactant, … Lung surfactant is a mixture of mainly phospholipids and specific proteins that is …
surfactant, … Lung surfactant is a mixture of mainly phospholipids and specific proteins that is …
[HTML][HTML] The Past and Future of Genetics in Pulmonary Disease-You Can Teach an Old Dog New Tricks
LM Nogee, A Hamvas - Pediatric pulmonology, 2020 - ncbi.nlm.nih.gov
… As an example, genetic disorders of surfactant metabolism result … respiratory failure to adult
onset pulmonary fibrosis (1-7). The lung histopathology diagnoses associated with surfactant …
onset pulmonary fibrosis (1-7). The lung histopathology diagnoses associated with surfactant …
Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers
E Guzmán - Coatings, 2022 - mdpi.com
… Once pollutants enter the alveolar cavity, they are deposited on the lung surfactant (LS) film,
altering their mechanical performance which increases the respiratory work and can induce …
altering their mechanical performance which increases the respiratory work and can induce …