… -derived xenografts (PDXs) and genetically engineered mouse models (GEMs), have been
… Among tumor pathologies, endocrine and neuroendocrine tumors represent a unique group …

… lung carcinoma and small cell carcinoma, with marked differences in … genetic landscape of
the human tumors, its influence in the development of genetically engineered mouse models (…

… data on mouse models for GEP-NEN. We discuss how these models reflect tumor biology of
… The most commonly used genetically modified mouse models for NENs are listed in online …

… In comparison to the … models as a potential tool for testing receptor-targeted theranostics,
we conducted a proof-of-concept study whereby we established a mouse model with tumor …

… Here we generated two genetically engineered mouse models (GEMMs) harboring … and
compared histopathology with the Men1 and Pten mouse models. Concomitant loss of Pten and …

… Popular models include cell lines, patient derived xenograft cells and animal models (ie,
genetically engineered mouse models (GEMMs)), while three-dimensional (3D) models have …

… advances in cancer research. Genetically engineered animal models, mainly in mice, have
… However, the pancreatic tumors also contained areas with neuroendocrine rather than …

… various mouse strains. Within this article, we will cover the principal mouse models used in
… humans, and continuing on with genetically engineered mice, microsurgical-induced cancer …

… murine models of high-grade neuroendocrine lung carcinomas generated by the loss of 4
tumor … of SCLC, thus differentially influencing the lung cancer type developed. So far, a defined …

… Loss of PTEN and TP53 has been associated with abiraterone resistance and progression
towards a small cell/neuroendocrine phenotype in genetically engineered (GEM) models (…