… natural proteins? This general question has been explored by analyzing the evolution of
different protein folds, for which the TIM barrel … of protein stability, folding, function and evolution. …

… Nonetheless, we were able to insert a new element into the TIM barrel without disrupting its
structural integrity or stability. The newly inserted 3 10 helix appears to fit even more snugly …

… Although the kinetic species are conserved, the evolution of the sequences over time has
resulted in alternative locations for the cores of stability in the TIM barrel architecture. …

… functions and its ubiquity in different types of enzymes, the TIM barrel represents a suitable
scaffold for protein … -fold symmetric TIM barrel was described: the sTIM11 protein. Considering …

… of TIM barrel proteins. We conclude that the folding mechanism of the IGPS TIM barrel, including
the structures of … core of stability around which adjacent elements of structure condense. …

… , we have created a homodimeric protein with a TIM barrel base and a dimeric FD lid … to
enzyme function. In this work, the TIM barrel component of the highly stable TFD scaffold was …

… the proteins encoded by the most probabilistic sequences at nodes N72, N73, and N125. While
the three proteins were active and stable… over time. We therefore selected the resurrected …

… This work applies the methodology to one of the ubiquitous TIM barrel proteins. … Enzyme
stability assays were performed to confirm that the enzyme remained fully active under the …

… Based on the new SAM complex structures, we propose that the mitochondrial β-barrel …
.60, 61 The first five proteins form a very stable core complex, while Tom70 and Tom20 readily …

… structure of “classical” bacterial β-barrel proteins in more detail and describe how the proteins
… Heat-modifiability can also be used to study structural stability of β-barrels by sampling the …