… the COX isoenzyme/variant targeted by paracetamol and on … FAAH inhibitor URB937 in
models of thermal hyperalgesia, … efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib …

… the site of injury (primary hyperalgesia) or extending into the sur… be used to decrease
paracetamol absorption. However, the … Cyclooxygenase-selective inhibition of prostanoid …

… The inhibition of the glutamate transporter leads to increased synaptic … parecoxib, parecoxib
plus dexmedetomidine and S (+)-ketamine plus methadone all have the potential to prevent …

… Coxibs (for instance, etoricoxib, celecoxib, and parecoxib/… In the CENTRAL NERVOUS
SYSTEM, paracetamol has been … production, NSAIDs reduce the hyperalgesia typical for …

… of the enzymes lipoxygenases and cyclooxygenases (COXs) on … displayed the most significant
inhibition for cPLA 2 . This … the COX-1 and COX-2 isozymes, consequently leading to the …

… and inflammation leading to hyperalgesia by sensitization of … and its intravenous prodrug,
parecoxib, given for pain treatment to … mechanism through which paracetamol could exert its …

… excludes a role of cyclooxygenase inhibitor but includes effects … or paracetamol) was
synthesized by Morse in 1873 via the … to a hyperalgesic state and suggest an effect upon central …

… peripheral sensitization to cause hyperalgesia. In response to … makes it a reversible inhibitor
of cyclooxygenase. In order to … The main reason behind these reactions is the inhibition of …

… Cyclooxygenase isoenzymes COX-1 and COX-2 catalyze … NSAIDs show some inhibition for
the cyclooxygenases 1 and … Rofecoxib has a central furanone ring and valdecoxib a central …

… 1 Multimodal analgesia (MMA) is a key part of ERAS protocols that reduce opioid exposure
while improving analgesia. In this review, we will explore current analgesic methods used by …