… pathways or factors contributed to positive or negative regulation of cyclooxygenase-2 (COX-2)
in cancer … variety of cancers (Figure 6), targeting COX-2 expression in cancer cells is a …

… the PI3K/Akt signaling pathway to induce tumor cell apoptosis. In … targeted drugs and
chemotherapy. Such a drug combination can also simultaneously target multiple molecular targets. …

… to prevent the potential risk when COX inhibitors are used for treatment of colorectal cancer.
… with other NSAID drugs that target other critical pathways in carcinogenesis. For example, …

… by inflammatory mediators, and also under hypoxic conditions and in many cancers. … The
final target of the different assayed compounds is the inhibition of the NFκβ signalling pathway …

… of those molecules in colon cancer in the context of PG/COX signaling pathways that could
be … all these data strongly suggest that Cox targeting is a mechanism for cancer prevention. …

… In this review, the role of COX-2 in GI cancers is explored, and its clinical … targeting of the
COX-2 and EGFR pathways in PC might be a potential strategy for PC treatment and prevention…

… Inhibition of COX-2/PGE2 signal pathway can recover the activation of NK cells in tumor-…
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 …

… this pathway in tumor immune escape, we will discuss how to target each component of this
pathway as … In conclusion, the COX-2-PGE2 pathway not only is an effective target for tumor …

… clarify the role of PGE2 in cancer progression and its targeting for treatment of colon cancer.
… signaling pathways may be considered as potent anti-colon cancer therapeutic approach. …

… to COX-2-targeted treatment in EMS, including COX-2 … survival and antiapoptotic pathways
to prevent cells from undergoing … in the development of gastric cancer, tumor-infiltrating Treg …