… It is a decades-long process characterized by gradual loss … While in bovine cartilage, leptin
alone or in synergy with IL-1 … In vivo experiment has showed that expression of ADAMTS-4/-5, …

… (ECM) of the articular cartilage, which leads to pain and … of variance (ANOVA) with Bonferroni’s
post hoc analysis was … decrease in the expression of ADAMTS-4. Furthermore, incubation …

… ADAMTS-4 and 5 are responsible for the breakdown of aggrecan… This characterization
is facilitated by our laboratory’s … In this study, we used an in vitro and ex vivo model of OA …

… Fixed charge density in cartilage can be measured visually with … ADAMTS1, ADAMTS-4
and ADAMTS-5 aggrecanase proteins … Ex vivo models of cartilage injury are used to study the …

… The ADAMTS-4/5 generated fragment with the N-terminus … human and bovine cartilage
explants (121, 127, 160-162). … ex vivo models of joint tissues as a tool for drug development …

… Undertake metabolomic and proteomic longitudinal analysis of an ex-vivo equine cartilage
explant osteoarthritis model (Chapter 4). 4. Compare the human synovial fluid metabolite …

… The catalytic domain is characterized as being the zinc-… cancer cell models and an orthotopic
mouse model of human … -9 measurements; MMP-9 serum was detected and measured …

… E2 (PGE2) release) were measured in bovine NP cells embedded in … In this thesis, in vitro
and in vivo models of … by editing cells to be transplanted ex vivo so that they can survive the …

… intrinsic characteristics and biomechanics of various cartilage … While ADAMTS-4 is elevated
in the serum of patients with … induced collagen release from bovine cartilage by upregulating …

… , is characterized by the progressive destruction of cartilage, … crossbite in vivo rat models,
the stimulator induced cartilage … incubating the chondrocytes of bovine cartilage tissue with IL-…