… E2 (PGE2) release) were measured in bovine NP cells embedded in … In this thesis, in vitro
and in vivo models of … by editing cells to be transplanted ex vivo so that they can survive the …

… of cartilage and bone tissue within the joint. Research into novel therapies is currently limited
by the throughput and replicative accuracy of early-stage in vitro disease models. … analysis …

… ODN or treatment with the activesite targeting small molecule uPA … into human cartilage
explants in the SCID RA xenograft model, … Utility of animal models for identification of potential …

… properties in vitro in cell models and in vivo in the mouse, … is characterized by the progressive
loss of articular cartilage … ability to regulate the activities of ADAMTS-4 and ADAMTS-5. …

… joints [1] characterized by chronic deterioration of the articular cartilage with altered subchondral
… Experimental studies in dogs have shown inhibition of ex vivo proteoglycan synthesis …

… PPS stimulates proteoglycan synthesis by bovine and ovine chondrocytes … models of Ross
River virus (RRV) and CHIKV disease have been used to characterize the extent of cartilage …

… larger role in cartilage differentiation in vivo and in vitro than if … tissue and characterized
using flow cytometric analysis. … increased the expression of ADAMTS-4 and -5 enzymes, …

… The Altmetric Attention Score is a quantitative measure of the … The degeneration of articular
cartilage in osteoarthritis (OA) … A one-way analysis of variance and posthoc Tukey’s test …

… characterized by the degeneration of articular cartilage, the … ADAMTS-4 and ADAMTS-5
are also aggrecanases that drive … established cell line are ex vivo transduced with a retrovirus …

… naturally with age and being characterized by a steep loss of … We started by assessing the
immunoregulatory capacity of … α whose presence dramatically increases ADAMTS-4/5 levels …