[HTML][HTML] The effect of LPA Thr3888Pro on lipoprotein (a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G> A
R Grüneis, C Lamina, S Di Maio, S Schönherr… - Atherosclerosis, 2022 - Elsevier
Background and aims High lipoprotein (a)[Lp (a)] concentrations are associated with
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the
LPA gene but involved genetic variants have not been fully elucidated. Improved
understanding of the entanglements of genetic Lp (a) regulation may enhance genetic
prediction of Lp (a) and CAD risk. We investigated an interaction between the well-known
LPA missense SNP rs41272110 (known as Thr3888Pro) and the frequent LPA splicing …
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the
LPA gene but involved genetic variants have not been fully elucidated. Improved
understanding of the entanglements of genetic Lp (a) regulation may enhance genetic
prediction of Lp (a) and CAD risk. We investigated an interaction between the well-known
LPA missense SNP rs41272110 (known as Thr3888Pro) and the frequent LPA splicing …
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