… non-K48-linked ubiquitylation can drive oncogenic pathways, has led to a … new roles of
non-proteolytic ubiquitylation in regulating oncogenic and tumor-suppressive signaling pathways …

… emerging role of USP19 as a previously unrecognized prognosis factor that possesses both
positive and negative regulation activities in tumor biology. These observations indicate that …

… protein stability and ubiquitination through the conjugation of ubiquitin to target proteins [22]…
oncogenic pathways (Table 1). We present selected E2 members with roles in cancer below. …

… their role in turning off the signaling by ubiquitin-mediated degradation, candidates RNF11
as the master regulator of a plethora of signaling pathways. … in modulating ubiquitin-regulated …

… as ubiquitin (Ub) (15). As delving into study of ubiquitination, key roles for the ubiquitination
has … Jin et al. summarized the role of ubiquitination in lung cancer such as tumor initiation, …

… an important role in regulating proteasome maintenance by regulating the expression of
the 26S subunit of the proteasome system, which helps facilitate the degradation of ubiquitin-…

… Ubiquitin modification regulates cellular functions by triggering protein degradation via the
proteasomal or lysosomal pathway, … oncogenic role, USP15 also antagonizes the E3 ubiquitin …

… of our knowledge of ubiquitin and Ubl-binding domains opens up many new questions,
only partially highlighted here. What is the functional role of ubiquitin/NEDD8 recognition in …

… A large variety of code generated via PTMs of proteins by ubiquitin (ubiquitination) and
ubiquitin-like proteins (Ubls), such as interferon (IFN)-stimulated gene 15 (ISG15), small …

… Then ubiquitin ligase E3 recognizes the substrate and facilitates the transfer of ubiquitin …
E3 ligases, known for their substrate specificity, are crucial in the ubiquitination pathway. The …