The natural history of integrons

TM Ghaly, MR Gillings, A Penesyan, Q Qi, V Rajabal… - Microorganisms, 2021 - mdpi.com
… Consequently, this class of integrons has become a … continue to drive environmental instability,
integrons will likely continue … ecological and evolutionary dynamics of integrons can help …

Integron activity accelerates the evolution of antibiotic resistance

C Souque, JA Escudero, RC MacLean - Elife, 2021 - elifesciences.org
… We observed a diversity of cassette re-arrangements as a result of integrase activity, whose
diverse prevalences can help us understand the evolutionary dynamics underlying cassette …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - Am Soc Microbiol
… some understanding of evolutionary dynamics, modeling and … a gene capture platform (as
an integron), which might, in turn… be untwisted in changing environments (blue bidirectional …

Integrons: antibiotic resistance evolution and beyond

PR Chowdhury, HW Stokes… - … integrative mobile genetic …, 2022 - taylorfrancis.com
… class 1 integrons into diverse general environments, ranging … Class 1 integrons are also
found in environmental samples … to the clinical class 1 integrons. The most definitive ones are …

Unbridled integrons: a matter of host factors

E Richard, B Darracq, C Loot, D Mazel - Cells, 2022 - mdpi.com
… exists between integrons and their hosts and its importance to face changing environments.
… factors have on the evolution of integrons. Indeed, we propose that sedentary chromosomal …

Integron functionality and genome innovation: an update on the subtle and smart strategy of integrase and gene cassette expression regulation

ÉL Fonseca, AC Vicente - Microorganisms, 2022 - mdpi.com
… effects and fitness burden, the integron activity must be tightly … and functionality of integrons
at both transcriptional and … integron expression is intricately related with environmental

Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure

C Souque, JA Escudero, RC MacLean - MBio, 2023 - Am Soc Microbiol
… Here, we test the evolutionary benefits of integron activity using bla VEB-1 , a β-lactam …
play a greater role in determining the evolutionary impact of integron activity. In this scenario, we …

Evolutions of antibiotic resistance genes (ARGs), class 1 integron-integrase (intI1) and potential hosts of ARGs during sludge anaerobic digestion with the iron …

Y Zhang, Z Yang, Y Xiang, R Xu, Y Zheng, Y Lu… - … of the Total Environment, 2020 - Elsevier
… Moreover, the evolutions of antibiotic resistance genes (ARGs), class 1 integrons-integrase
(intI1) and potential hosts of ARGs were also investigated. The optimal addition of Fe 3 O 4 …

[HTML][HTML] Dynamics of integron structures across a wastewater network–Implications to resistance gene transfer

M Quintela-Baluja, D Frigon, M Abouelnaga, K Jobling… - Water Research, 2021 - Elsevier
… Here we examine integron dynamics by quantifying different integrons and microbiota
across a wastewater network that includes community and hospital sources, sewer lines, a …

[HTML][HTML] Functional enrichment of integrons: Facilitators of antimicrobial resistance and niche adaptation

TM Ghaly, V Rajabal, A Penesyan, NV Coleman… - Iscience, 2023 - cell.com
… -environment” interactions were mainly involved with detoxification, stress tolerance,
environment… to adapt and thrive under changing environmental conditions. Potential virulence …