… results in more repression of mRNA translation, thereby … As part of activity-dependent
translation, mGluR activity can … these proteins is cytoplasmic Fmr1interacting protein 1 (CYFIP1)…

… The knockdown of Cyfip1 in cortical neurons in vitro increases the translation of FMRP …
fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP…

… CYFIP1 also interacts with fragile X mental retardation protein (FMRP) [21], a protein related
to fragile X syndrome (… (4E-BP), forming a posttranscriptional regulatory complex with FMRP …

… S6K or 4E-BP proteins (Figure 1) (134). … CYFIP1-FMRP-eIF4E complex, that represses the
translation initiation. Consequently, a bigger amount of eIF4E is bound to eIF4G, while CYFIP1 …

… , the Fragile X Syndrome are associated with alterations in dendritic spine morphology,
thereby pointing to dysregulated actin dynamics during … CYFIP1 acts as a eukaryotic translation …

… provided further insight into how FMRP represses target mRNA translation via RNAi. A …
Synaptic plasticity refers to the adaptability of synaptic transmission in an activity-dependent …

… from relatively common diseases like Fragile X Syndrome (FXS), to … CYFIP1 acts as a
non-canonical 4E-BP in this complex by … causes CYFIP1 to move from the translation repression …

… protein that interacts with FMRP (fragile X mental retardation … ) translation at synapses in
an activity-dependent manner (21,… CYFIP1 represses the translation of its target mRNAs by …

… to the synapses in an activity dependent manner through the association with microtubules
… represses translation of these mRNAs. However, the CYFIP1- mediated block in translation …

… We performed surface sensing of translation assay (76) to measure relative protein synthesis
rates in human fibroblasts (58). No differences in puromycin incorporation were observed …