… show that SIX1 also acts as a repressor of cell senescence, an … To assess p16Ink4a expression
in tumors with SIX1 … that the homeoprotein SIX1 is a negative regulator of senescence 5 , …

… Aberrant expression of this homeoprotein has therefore been … , both SIX1 over-expressing
cells and the control cells get … SIX1 inhibits cellular senescence by regulating p16INK4A …

… that the SIX1 homeoprotein, an essential regulator of organogenesis, is also a repressor of
adult cellular senescence. … The homeoprotein SIX1 controls cellular senescence through the …

… SIX1 promotes multiple hallmarks and enabling characteristics of cancer via regulation of cell
proliferation, senescence… observed between SIX1 and control tumors, SIX1 likely increased …

… and cancer cell proliferation. Using IPF patient samples and healthy controls, Six1 and both
of … data that explores the role of cellular senescence in the context of Six1 in lung fibrosis. …

… SIX1 can also regulate cellular senescence by the regulation of p16INK4A and
differentiation-related genes (47). … In this study, senescence-related genes were found to control …

… p16INK4A mediates senescence via the retinoblastoma … /p16 transcriptional control during
replicative senescence in … participated in cell senescence via transcriptional regulation of …

… SIX1 also helps in the epigenetic control of p16INK4A (cyclin-dependent kinase inhibitor 2A,
… The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A …

… Using the replication-competent avian sarcoma-leukosis … with Six1 overexpression to isogenic
controls with an otherwise identical genetic composition. In our studies, we found that Six1 …

… SIX1 in human fibroblasts represses senescence and stemness through the control of p16INK4a
… to the direct involvement of these two homeoproteins in the control of early epaxial Myf5 …