Vascular and neural basis of the BOLD signal

PJ Drew - Current opinion in neurobiology, 2019 - Elsevier
… localized hemodynamic signals that will allow high-field MRI to … without inducing calcium
signals in astrocytes [55]. Recent … independent of neural activation [100]. Studies have shown …

[HTML][HTML] Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics

F Tesler, ML Linne, A Destexhe - Scientific Reports, 2023 - nature.com
… ” we show that a calcium-driven Hemodynamic Response Function (… Finally, in Section
Adaptation effects we study the effects of … involved in the calcium signal activation, and a detailed …

More than just summed neuronal activity: how multiple cell types shape the BOLD response

C Howarth, A Mishra, CN Hall - … Transactions of the …, 2021 - royalsocietypublishing.org
Activation of excitatory neurons in the brain is believed to initiate the … , astrocytes may drive
neurovascular coupling in two ways: fast calcium signals that fine-tune the haemodynamic

Dynamics of the cerebral blood flow response to brief neural activity in human visual cortex

JH Kim, AJ Taylor, DJJ Wang… - … Cerebral Blood Flow & …, 2020 - journals.sagepub.com
… minimize partial volume effects from outside of the gray matter. We treated the signal observed
in … evoked by neural activation, fundamentally changing the hemodynamics of the BOLD …

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

A Das, K Murphy, PJ Drew - … Transactions of the Royal …, 2021 - royalsocietypublishing.org
… It is important to keep these likely functional roles in mind when designing brain imaging
[107] and has been shown to relate to functional networks activated by particular tasks [108]. …

Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity

A Mishra, CN Hall, C Howarth… - … Transactions of the …, 2021 - royalsocietypublishing.org
signals during neural activation, thus yielding BOLD signals. In … , with the contribution of
astrocytes being most prominent at the … effect of such components on the haemodynamic signals

Hemodynamic response function description in patients with glioma

S Chabert, R Salas, E Cantor, A Veloz, A Cancino… - Journal of …, 2024 - Elsevier
… , brain vessels are invaded by tumoral cells, astrocytes are … mixed-effects model, over more
than 600 activated clusters, … present study no age or sex effect on HRF was detected in the …

[HTML][HTML] Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses

AJ Poplawsky, B Iordanova, AL Vazquez, SG Kim… - Neuroimage, 2021 - Elsevier
… First, to examine if postsynaptic activation of these inhibitory … also increase blood flow
through astrocytes, we applied 1-… Lastly, we examined the effects of GABA on the hemodynamic

[HTML][HTML] Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

A Institoris, M Vandal, G Peringod, C Catalano… - Nature …, 2022 - nature.com
astrocyte Ca 2+ signals (>3 s) occurring in the awake state regulate CBF when sensory
activation … In response to 5 s whisker stimulation, we found that astrocyte CalEx had no impact on …

Imaging neuronal and astrocytic Ca2+ transients and hemodynamic responses evoked by single stimulation in rodent cortex

W Chen, K Park, X Gu, Y Pan… - Neural Imaging and …, 2020 - spiedigitallibrary.org
… in neurovascular coupling during the cortical activation and during the resting states of brain
… and the phase of ongoing activity can impact the level of stimulation-evoked responses. …