… up-regulated in mTOR-deficient M-MDSCs, which explained the enhanced cell differentiation
and immunosuppressive … role of cellular metabolism in immune cell mTOR signaling (25). …

… the differentiation of M-MDSCs into immunosuppressive … Whereas in the hypoxic TME,
M-MDSCs can differentiate into … ) also significantly regulated the immunosuppressive activities of …

… for T cell functions, expression of ectoenzymes regulating … and impairs further differentiation
of progenitor cells, leading … phosphorylation of extracellular signal–regulated kinase (ERK), …

… of immunosuppressive cell types such as myeloid-derived suppressor cells (MDSC). … CREB
has previously been shown to regulate myeloid differentiation among others by controlling …

… an immunosuppressive … the differentiation and functions of T lymphocytes by regulating
their energy metabolism [2, 22]. These observations clearly indicate that AMPK signaling controls …

… stem cells (HSC) in bone marrow first differentiate into … , immunosuppressants are the main
means of regulating the … -IDO signaling pathway, and that these MDSCs also regulated T …

… their differentiation into immunosuppressive macrophages [49,… (mTOR) signaling, to sustain
their metabolic activity, Treg express low levels of GLUT-1, are negatively regulated by mTOR…

… differentiation, but the mechanism by which autophagy regulates the development of early-stage
myeloid-derived … and exacerbated immunosuppression in vitro and in vivo. We found …

… and a population lacking both differentiation surface markers … immunosuppressive regimens
used (tacrolimus and mTOR inhibitors) or whether MDSC subsets are differentially regulated …

… leukemic cells may influence the growth and differentiation of … immunosuppression
contribution, regulate myeloid leukemia … AML cells by mTOR signaling pathway activation [124]. …