Peripheral nitric oxide signaling directly blocks inflammatory pain
… by enzymes called nitric oxide synthases (NOS). … the involvement of the NO-signaling [92].
A role for K + ATP modulation in the final step of the morphine–NO peripheral antinociceptive …
A role for K + ATP modulation in the final step of the morphine–NO peripheral antinociceptive …
[HTML][HTML] Analgesic mechanism of sinomenine against chronic pain
W Jiang, W Fan, T Gao, T Li, Z Yin, H Guo… - Pain Research and …, 2020 - hindawi.com
… to have both pro and antinociceptive properties. For instance… by three isoforms of nitric oxide
synthases (NOSs), which … about how INF-c has participated in the establishment of chronic …
synthases (NOSs), which … about how INF-c has participated in the establishment of chronic …
[HTML][HTML] Prolonged use of NMDAR antagonist develops analgesic tolerance in neuropathic pain via nitric oxide reduction-induced GABAergic disinhibition
J Li, L Zhang, C Xu, YH Lin, Y Zhang, HY Wu, L Chang… - …, 2020 - Elsevier
… of NMDAR antagonists produces antinociceptive efficacy in … of nitric oxide (NO) from neuronal
nitric oxide synthase (nNOS)… 95–nNOS–NO cascade is not involved in the enhancement of …
nitric oxide synthase (nNOS)… 95–nNOS–NO cascade is not involved in the enhancement of …
Neuronal nitric oxide synthase suppression confers the prolonged analgesic effect of sciatic nerve block with perineural dexamethasone in postoperative pain model …
K Matsuda, M Sasaki, H Baba, Y Kamiya - The Journal of Pain, 2022 - Elsevier
… NOS and that p-p38 MAPK may not be involved in this phenomenon… -nitric oxide synthase
(NOS) inhibitor, on antinociceptive response … Several drugs have been reported to extend the …
(NOS) inhibitor, on antinociceptive response … Several drugs have been reported to extend the …
… central and peripheral anti-nociceptive activities of α-asarone through the inhibition of TNF-α production, leukocyte recruitment and iNOS expression, and participation …
… Moreover, leukocyte migration, inducible nitric oxide synthase … , several antagonists were
used on formalin and LPS-induced … several drugs are capable of promoting antinociception by …
used on formalin and LPS-induced … several drugs are capable of promoting antinociception by …
The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation
RCM Ferreira, DL de Almeida… - … Journal of Pain, 2022 - Wiley Online Library
… the possible involvement of the nitric oxide synthase (NOS) … Although many studies have
shown the involvement of … /K ATP pathway and consequent analgesia. The components of this …
shown the involvement of … /K ATP pathway and consequent analgesia. The components of this …
[HTML][HTML] Blockade of NMDA receptors and nitric oxide synthesis potentiated morphine-induced anti-allodynia via attenuating pain-related amygdala pCREB/CREB …
… analgesic drug, is commonly used to alleviate different types of … the involvement of the
amygdala NMDA receptors and NO … periaqueductal gray-mediated antinociceptive effects of NMDA…
amygdala NMDA receptors and NO … periaqueductal gray-mediated antinociceptive effects of NMDA…
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice
T Komatsu, S Katsuyama, F Takano, T Okamura… - Neuroscience …, 2019 - Elsevier
… analgesia, we assessed the phophorylation of ERK1/2 in the … has multiple pharmacological
antinociceptive activities. The … the increases in the neuronal nitric oxide synthase (nNOS) …
antinociceptive activities. The … the increases in the neuronal nitric oxide synthase (nNOS) …
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system
JA Petrocchi, DL de Almeida, P Paiva-Lima… - European journal of …, 2019 - Elsevier
… in the mechanism of peripheral analgesia induced by ketamine… neuronal nitric oxide synthase
(nNOS) enzyme to produce … ketamine might be participating in the synthesis and release of …
(nNOS) enzyme to produce … ketamine might be participating in the synthesis and release of …
[PDF][PDF] Receptor and molecular targets for the development of novel opioid and non-opioid analgesic therapies
R Chen, M Coppes, RD Urman - Pain Physician, 2021 - painphysicianjournal.com
… We characterize their antinociceptive mechanisms of action and … Nitric Oxide Synthase
Inhibitors Nitric oxide synthases (NOS) convert l-arginine into nitric oxide, a molecule involved in …
Inhibitors Nitric oxide synthases (NOS) convert l-arginine into nitric oxide, a molecule involved in …