Peripherally acting opioid analgesics and peripherally-induced analgesia
V Martínez, R Abalo - Behavioural pharmacology, 2020 - journals.lww.com
… opioid-related peripheral antinociceptive activity. These include … partially, with the participation
of opioid receptors located in … treat the many painful syndromes that originate in peripheral …
of opioid receptors located in … treat the many painful syndromes that originate in peripheral …
The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone
NT Cecilio, GR Souza, JC Alves‐Filho… - Fundamental & …, 2021 - Wiley Online Library
… be involved in the peripheral antinociceptive … analgesic effect of DIP in PGE2-induced
hyperalgesia was drastically reduced by treatment with a neural isoform of nitric oxide synthase (…
hyperalgesia was drastically reduced by treatment with a neural isoform of nitric oxide synthase (…
Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: potential underlying mechanisms and insight into the role of pain modulators
… to developing safe and effective drugs. In the present study, … for its analgesic and anti-inflammatory
potentials in different … possible involvement during EEOR-induced anti-nociception …
potentials in different … possible involvement during EEOR-induced anti-nociception …
The Antinociceptive responses of MTDZ to paclitaxel− induced peripheral neuropathy and acute nociception in mice: behavioral, pharmacological, and biochemical …
KP da Motta, CC Martins, VM Macedo, BF Dos Santos… - Pharmaceuticals, 2023 - mdpi.com
… mechanisms for therapeutic modulation of analgesic drugs. … with the upregulation of inducible
nitric oxide synthase (iNOS), … the pathways involved in the acute antinociceptive action of …
nitric oxide synthase (iNOS), … the pathways involved in the acute antinociceptive action of …
Participation of the cannabinoid system and the NO/cGMP/KATP pathway in serotonin-induced peripheral antinociception
DD Aguiar, JA Petrocchi, GC da Silva, VS Lemos… - Neuroscience …, 2024 - Elsevier
… peripheral antinociception, without causing analgesia, when … serotonin leads to increased
NO synthesis, we used the non-… of several types of analgesics, including SNC8, anandamide, …
NO synthesis, we used the non-… of several types of analgesics, including SNC8, anandamide, …
The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation
RCM Ferreira, DL de Almeida… - … Journal of Pain, 2022 - Wiley Online Library
… the possible involvement of the nitric oxide synthase (NOS) … Although many studies have
shown the involvement of … /K ATP pathway and consequent analgesia. The components of this …
shown the involvement of … /K ATP pathway and consequent analgesia. The components of this …
[HTML][HTML] Involvement of the L-arginine/nitric oxide/cyclic GMP/KATP channel pathway and PPARγ receptors in the peripheral antinociceptive effect of carbamazepine
B Ghorbanzadeh, V Kheirandish… - Drug Research, 2019 - thieme-connect.com
… In conclusion, carbamazepine induced a peripheral antinociceptive … on NO synthesis. Results
showed that carbamazepine-… role in the peripheral analgesic effect of several drugs in the …
showed that carbamazepine-… role in the peripheral analgesic effect of several drugs in the …
[HTML][HTML] Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review
H Hermanns, MW Hollmann, MF Stevens, P Lirk… - British journal of …, 2019 - Elsevier
… to further unravel these antinociceptive mechanisms, which … the mechanisms involved in the
antinociceptive action of … of the enzyme, NO synthase (NOS), catalysing NO formation from L-…
antinociceptive action of … of the enzyme, NO synthase (NOS), catalysing NO formation from L-…
… Receptors and l-Arginine-Nitric Oxide-Cyclic Guanosine Monophosphate-ATP-Sensitive K+ Channel Pathway in the Antinociceptive Activity of Cardamonin in Acute …
… as the positive control drug, showed significant inhibition, … also caused disturbance in motor
coordination, but these two … nitric oxide synthase (NOS) to produce a sufficient amount of …
coordination, but these two … nitric oxide synthase (NOS) to produce a sufficient amount of …
Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms
W Barra, B Queiroz, A Perez, T Romero… - Naunyn-Schmiedeberg's …, 2024 - Springer
… -activated) are involved in this mechanism. However, the role … , for analgesia, the reverse
direction of the pathway seems not … of NO derived from its production by nitric oxide synthases (…
direction of the pathway seems not … of NO derived from its production by nitric oxide synthases (…