[HTML][HTML] Prospects for the personalized multimodal therapy approach to pain management via action on NO and NOS
NA Shnayder, MM Petrova, TE Popova, TK Davidova… - Molecules, 2021 - mdpi.com
… of NO and NO synthases (NOS) isoforms in peripheral pain … involvement of the NO-cGMP
pathway in the antinociceptive … the NO-cGMP pathway on the analgesic effect of some drugs for …
pathway in the antinociceptive … the NO-cGMP pathway on the analgesic effect of some drugs for …
Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies
Y D'Arcy, P Mantyh, T Yaksh, S Donevan… - … Medicine, 2021 - Taylor & Francis
… (eg peripheral sensitization, central sensitization, neuronal sprouting) possibly involved in
OA-related nociception, there are several pathways that can be targeted to achieve analgesia. …
OA-related nociception, there are several pathways that can be targeted to achieve analgesia. …
[HTML][HTML] Blockade of NMDA receptors and nitric oxide synthesis potentiated morphine-induced anti-allodynia via attenuating pain-related amygdala pCREB/CREB …
… analgesic drug, is commonly used to alleviate different types of … the involvement of the
amygdala NMDA receptors and NO … periaqueductal gray-mediated antinociceptive effects of NMDA…
amygdala NMDA receptors and NO … periaqueductal gray-mediated antinociceptive effects of NMDA…
[HTML][HTML] Antinociceptive effect of Mansoa alliacea polar extracts involves opioid receptors and nitric oxide in experimental nociception in mice
MG Valle-Dorado, A Hernández-León… - Biomedicine & …, 2022 - Elsevier
… by L-NAME (inhibitor of nitric oxide synthase), but not by ODQ (… For this, its participation in
the antinociceptive effect of MA … mechanisms such as the participation of ON as an analgesic …
the antinociceptive effect of MA … mechanisms such as the participation of ON as an analgesic …
[HTML][HTML] Topical treatments and their molecular/cellular mechanisms in patients with peripheral neuropathic pain—narrative review
M Kocot-Kępska, R Zajączkowska, J Mika, DJ Kopsky… - Pharmaceutics, 2021 - mdpi.com
… insight into the peripheral mechanisms involved [9]. The injury of … Whether these mechanisms
play a role in pain relief … The possible mechanisms of antinociception of topical treatments …
play a role in pain relief … The possible mechanisms of antinociception of topical treatments …
[HTML][HTML] Inhibition of fast nerve conduction produced by analgesics and analgesic adjuvants—Possible involvement in pain alleviation
E Kumamoto - Pharmaceuticals, 2020 - mdpi.com
… clinically-used antinociceptive drugs such as many kinds of opioids … the antinociceptive
drugs affect mammalian peripheral nerve … mechanism for antinociception induced by analgesic …
drugs affect mammalian peripheral nerve … mechanism for antinociception induced by analgesic …
[HTML][HTML] Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study
… action through the inhibition of nitric oxide synthase and cyclooxygenase-2, in vivo and in …
inflammatory and analgesic properties [1, 9, 25], we investigated if Pellucidin A was involved in …
inflammatory and analgesic properties [1, 9, 25], we investigated if Pellucidin A was involved in …
[HTML][HTML] Overview of neurological mechanism of pain profile used for animal “pain-like” behavioral study with proposed analgesic pathways
… coupled with the mechanism of the action that is involved. Thus, … methods induced by different
phlogogenic agents, the different … and measuring the peripheral analgesic activity [6,99]. …
phlogogenic agents, the different … and measuring the peripheral analgesic activity [6,99]. …
[HTML][HTML] Flavonoids alleviate peripheral neuropathy induced by anticancer drugs
… Besides these, other neuroinflammatory mechanisms are involved … nitric oxide synthase
(iNOS) activity, and thereby induces … paclitaxel induce neuropathy through different mechanisms […
(iNOS) activity, and thereby induces … paclitaxel induce neuropathy through different mechanisms […
Role of endocannabinoid system in the peripheral antinociceptive action of aripiprazole
RCM Ferreira, AF Almeida-Santos… - … & Analgesia, 2019 - journals.lww.com
… of many non-CB agonists has been evaluated in several … manner, 10 supporting the use
of these drugs in this study. … the participation of AEA in the antinociceptive effect induced by …
of these drugs in this study. … the participation of AEA in the antinociceptive effect induced by …