… or indirectly induces nociceptive responses and in many cases … nNOS activation not only
enhances the antinociception of … mainly involved in the research and production of medicines …

… Tapentadol, an analgesic with a dual mechanism of action, … that the nitric oxide synthase
(NOS) system is one of many … to evaluate the involvement of NO in the two mechanisms of …

… antinociceptive effect was abrogated by administration of LNMMA (a nitric oxide synthase …
to prevent mechanical hyperalgesia induced by PGE 2 , the main mediator involved in the …

… the most effective and widely used drug in several solid tumors, … -neuronal cells strongly
involved in chemotherapy-induced … antinociceptive or analgesic drugs, such as morphine, which …

… descending anti-nociception, thus reducing the analgesic … and chemokines; inducible
nitric oxide synthase (iNOS) and … (COX)-2 involved in prostaglandin synthesis. IKK IκB kinase …

… In the present study two other models (the formalin and … these drugs had no impact on
sitagliptin's antinociceptive action, … of NO synthase has produced both analgesic and anti-…

… new analgesic drugs while improving their efficacy and safety. … ; L-arginine, nitric oxide (NO)
precursor; L-NAME, NO synthase (… the participation of the L-arginine/NOS/NO pathway in the …

… After 24 h, the antinociceptive effect of DALDA was completely … We further examined
mechanism for pain-relief via peripherally … the involvement of reward circuitry in DALDA-induced …

… and animal experimentation procedures to produce analgesia… mechanisms involved in
peripheral antinociception induced … effects of xylazine have been described by several authors. …

… are many investigations about the effects of the analgesics … but the latter two drugs also
produced antinociception in a … to lamina II neurons is involved in antinociception is supported …