… Accumulating evidence suggests the involvement of many … -regulation of NOS1 (Nitric Oxide
Synthase 1) gene whereas … to the anti-nociception which necessitates the increase in drug …

… Alterations of multiple molecular pathways have been … that the suppression of nitric oxide
synthase (NOS) activity [52] … spinal cord neurons, which is involved in antinociceptive tolerance […

… (PMN) leukocytes and inducible nitric oxide synthase (iNOS) … On the basis of EODf anti-inflammatory
activity, the analgesic … to be involved in the central and peripheral antinociceptive …

… nitric oxide synthases … SPMs act not only at the peripheral site of injury, but also participate
in the CNS … , and its activation is required for RvE1’s antinociceptive action in inflammatory …

… out to determine the peripheral antinociceptive effect of the … which serotonin and histamine
are involved, secondary phase (… by three isoforms of nitric oxide synthase (NOS) including …

… Effects of pretreatment with different nitric oxide synthase (NOS) … that NO is involved in
the antinociceptive action of analgesics such as opioids, nonsteroidal anti-inflammatory drugs, …

… , it would participate in the decreased antinociceptive efficacy of … need for opioid analgesic
medication. The existence of opioid-… Several studies have demonstrated the involvement of …

… ), several interleukins and inducible nitric oxide synthase (… 1), participate in the analgesic
actions of several compounds such … paw expression of MOR induced by this drug, we evaluated …

… NOS (Nitric oxide synthase) expression has been reported to … L-NAME did not alter the
analgesic effect of imperatorin. … Antinociceptive and anti-inflammatory effects of myricetin 3-O…

… as several groups are demonstrating the involvement of these phenolic compounds as
anti-inflammatory, analgesic, … oxidase and inducible nitric oxide synthase [163]. These mediators …