… pain, and morphine tolerance. The main process in the NO/… the NO/cGMP signaling pathway
plays an important role in the … NO/cGMP/PKG signaling has algesic and analgesic effects in …

… desensitization and tolerance. These … importance of the NO pathway for the peripheral
analgesic effects of different substances suggests that this is not simply a mere signaling pathway, …

… a significant analgesic tolerance, as indicated by its efficacy that significantly decreased over
… may affect central sensitization through a different signal pathway, such as glia activation, …

… analgesics have either limited therapeutic effects or serious … , and nitric oxide synthase (NOS).
It is reported that NO and … many signal pathways in the body, NO/cGMP/PKG pathway and …

… role of l-arginine/nitric oxide (NO)/cyclic GMP (cGMP)/K ATP in the antinociceptive responses
of various analgesics, the role of this signaling pathway … the significant role of cGMP and K …

… Kinase (MAPK), altered intracellular signaling pathway including nitric oxide, and activation
of … nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic …

… detail, there still appears to be a pivotal role for nitric oxide, as well as both intracellular and
… play on the role of nitric oxide (NO) as a proposed key mediator of opioid analgesic tolerance…

… effects [9], improved insulin resistance in high fructose-fed rat … by the l-arginine-nitric
oxide-cyclic GMP pathway [30,31]. Thus, … kinase C signalling pathway plays an important role in …

… NOS system plays an important role in the attenuation of tapentadol-induced tolerance and
… treatment may result in the development of analgesic tolerance and if it carries an increased …

… far of the VEGF signaling pathway, which has been shown to … , diabetes, insulin resistance,
obesity and hyperlipidemia are … novel analgesic agents that target eNOS without significant …