… pain generator in chronic conditions. Selective destruction of noradrenergic neurons appears
to dampen neuropathic pain … of the noradrenergic system in long-term pain. Stronger c-Fos …

… locus coeruleus (LC) plays a paradoxical role in chronic pain. … transform the LC into a
chronic pain generator. We sought to … locus coeruleus-noradrenergic (LC-NE) system in chronic …

… of noradrenaline in acute and chronic trigeminal pain conditions and how the activity of
the locus coeruleus noradrenergic neurons changes in response to acute and chronic pain …

… of AR, and the intensity and duration of the pain stimulus [22,23]. Our … pain facilitation by
showing that, in chronic pain models, NA released from the LC in the brain accounts for pain …

… pain (chronic constriction injury), we explore how this comorbidity arises. To this end, we
evaluated the time-dependent plasticity of noradrenergic locus coeruleus … in chronic pain and …

… locus coeruleus on non-coerulean, discrete noradrenergic cell group(s). We implemented
locus coeruleus … the role of the locus coeruleus as a ‘chronic pain generator’. Pinpointing the …

… a source of pain inhibition but also a chronic pain generator. Furthermore, it also explains
the limited efficacy of systemic drugs increasing global noradrenaline availability. Therefore, …

… to chronically ablate LC noradrenergic … noradrenergic neurons that acts through noradrenaline
transporter uptake mechanisms, 40 we observed a significant reduction in noradrenergic …

… locus coeruleus integrity measured by locus coeruleus … (LC CNR ) in people with and without
chronic pain. On this scale, 0 … noradrenergic locus coeruleus as a chronic pain generator. …

… However, the LC is also known to be involved in maintaining chronic pain states, 10 and
recent studies suggest that descending NA-containing projections are involved in generating …