… Identified lower rostral-middle locus coeruleus integrity in men with chronic pain. …
gabapentinoids 53 and serotonin-norepinephrine reuptake inhibitors markedly inhibited neuropathic …

… We implemented locus coeruleus (LC) targeting strategies by microinjecting CAV-PRS-… to
chronic pain when considering the modular functional organisation and ‘chronic pain generator…

… A wide range of neuropeptides are found in the amygdala, particularly in the CeA, but
this review will discuss those neuropeptides that have been explored for their role in pain …

… The electrode lead(s) are connected to an implanted pulse generator, which … and locus
coeruleus, 110 , 111 which in turn drive descending inhibition via serotonergic and noradrenergic …

… , or freeze response, regulating wakefulness and arousal, and modulating pain through
descending projections to the rostral ventromedial medulla (RVM) and locus coeruleus (LC). …

… locus coeruleus (LC) in the dorsal pons is the source for actions of its main neurotransmitter
noradrenaline … this system a powerful encoder and generator of spatiotemporal patterns with …

… The locus coeruleus (LC) in the pons of the brainstem provides the sole source of
noradrenergic afferent input to most brain structures including the cerebral cortex, hippocampus, …

… -noradrenergic receptor expression in the spinal cord and the contralateral locus coeruleus
… states, however, this descending inhibitory system is believed to switch to a pain generator …

… reward processing in chronic pain conditions 41 . Projections from the locus coeruleus to the
prefrontal cortex… The locus coeruleus is the principal generator of noradrenaline in the CNS. …

… of chronic pain. Through an exploration of the anatomical and physiological pathways of
chronic pain, … of action, clinical utility, and future perspectives in chronic pain management. …