… impairment in the locus coeruleus and nucleus raphe magnus… Noradrenaline and serotonin
reuptake inhibitors, Parkinson's … Persistent nociceptive input in chronic pain conditions leads …

… noradrenergic system from the locus coeruleus to the dorsal horn of the spinal cord. Indeed,
the locus coeruleus is the largest noradrenergic … 50% of all noradrenergic neurons [Citation…

… In addition to its role as a relay in ascending pain pathways, … the descending pain modulation
system (raphe, locus coeruleus, … of norepinephrine and serotonin from the locus coeruleus …

… for patients with intractable chronic pain conditions. Chronic pain is a widely heterogenous
… with multiple options to treat refractory chronic pain. While compelling evidence for safety …

… The noradrenergic locus coeruleus (LC) is vital for brain states underlying wakefulness,
whereas its roles for sleep remain uncertain. Combining mouse sleep-wake monitoring, …

… locus coeruleus, the ipsilateral pontine nucleus as well as the contralateral nucleus of the
solitary tract (see Figure 4, Table 1). Since n = 4 participants perceived all stimulations as …

… that locus coeruleus-driven noradrenaline plays an overall pain-… of chronic pain. Indeed,
the selective disruption of … The noradrenergic locus coeruleus as a chronic pain generator. …

… A third and significant pathway in relation to the present thesis is the ascending modulation
from the locus coeruleus (LC) and how this could adjust the weighting of the predictive …

… To do so, we leveraged the endogenous properties of the mouse locus coeruleus noradrenergic
(… alleviate the comorbid hypersensitivity and anxiodepressive symptoms in chronic pain. …

… generators and/or autonomic effector pathways to the pupils. … processes or deplete
noradrenergic stores, thereby … or apply more broadly to patients with chronic pain in an upper or …