… light on the connection between chronic stress and chronic pain and their impact on the …
locus coeruleus is the main center of norepinephrine release. The release of norepinephrine is …

… through an implantable pulse generator or an external stimulation … Brainstem nuclei such
as the locus coeruleus and the … studies do definitely result in chronic pain, the rather exclusive …

… nuclei, parabrachial nucleus, and locus coeruleus (LC) in the … In the pons, the LC is a source
for noradrenergic input to the … of chronic pain and in individuals suffering from chronic pain. …

… techniques for treating chronic pain. We present evidence that … have long implicated spinal
noradrenergic signaling as a key … ensure adequate pain relief before the pulse generator and …

… Some of these pathologies involve neuronal structures that are called central pattern
generators (CPGs), which are involved in the production of rhythmic activities throughout the …

… generator’. Within the descending pathways, chemogenetic … It is known that DNIC are
subserved by noradrenergic signalling … descending locus coeruleus modules. Neurones within the …

… The norepinephrine neurons in locus coeruleus (LC-NE neurons) are essential for sleep
arousal, pain sensation, and … The noradrenergic locus coeruleus as a chronic pain generator. …

… (6 weeks after nerve injury) 47, suggesting an overactivation of the noradrenergic system
in longterm pain. Furthermore, optogenetic activation of the LC-ACC projection enhances …

… Intrathecal norepinephrine induced mechanical pain hypersensitivity via α 1A -… locus
coeruleus–noradrenergic signaling onto Hes5 + astrocytes. Moreover, in a model of chronic pain, α …

… ‘pain physiology’, ‘acute pain’, ‘chronic pain’, ‘chronic post-… Noradrenaline itself can activate
nociceptors setting in place … magnus (NRM) and the locus coeruleus (LC) and these form the …