Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome

H Sugita, S Nakanuma, S Munesue… - Journal of …, 2024 - Wiley Online Library
hepatectomy is important for patients with colorectal liver … of cilostazol (CZ), an oral selective
phosphodiesterase III … VWF in zone 3 and the increase in blood HA levels after hepatectomy …

Cilostazol induces apoptosis and inhibits proliferation of hepatocellular carcinoma cells by activating AMPK

KH Sim, MS Shu, S Kim, JY Kim, BH Choi… - Biotechnology and …, 2021 - Springer
… Kollmar, and MD Menger (2014) The phosphodiesterase 3 inhibitor cilostazol does not
stimulate growth of colorectal liver metastases after major hepatectomy. Clin. Exp…

Phosphodiesterase 3A represents a therapeutic target that drives stem cell–like property and metastasis in breast cancer

N Hao, W Shen, R Du, S Jiang, J Zhu, Y Chen… - Molecular Cancer …, 2020 - AACR
… the stemness of colorectal cancer. More interestingly, it … -selective inhibitor cilostazol
reduces breast cancer cell stem cell… –metastasis environment are thought to promote breast …

Influence of Mesenchymal Stem Cell Administration on the Outcome of Partial Liver Resection in a Porcine Model of Sinusoidal Obstruction Syndrome

R Palek, J Rosendorf, A Maleckova… - Anticancer …, 2020 - ar.iiarjournals.org
colorectal liver metastases, the possibility for radical liver resection … prevented SOS
development after HSCT (35). As it … was to evaluate whether administration of MSC can improve

cAMP signaling in pathobiology of alcohol associated liver disease

M Elnagdy, S Barve, C McClain, L Gobejishvili - Biomolecules, 2020 - mdpi.com
… rate of degradation by phosphodiesterases. cAMP signaling … six weeks followed by 70%
partial hepatectomy (PH) [100]. … ) and the PDE3 inhibitor, Cilostazol, on liver injury has also been …

A critical analysis of experimental animal models of sinusoidal obstruction syndrome

A Kumar, R Palek, V Liska - Journal of clinical and experimental …, 2019 - Elsevier
… for colorectal liver metastases (CRLM). Clinically, the disease … ) of these adaptations will
allow us to improve our analysis and … rats underwent 70% partial hepatectomy. Similarly, in a …

Platelet, Antiplatelet Therapy and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review

A Boccatonda, L Del Cane, L Marola, D D'Ardes… - Life, 2024 - mdpi.com
… a partial hepatectomy, and it was related to hepatocyte … cancer preventatives, particularly
in the context of colorectal … with T2DM, cilostazol has demonstrated the ability to inhibit the …

Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies

ROS Soares, DM Losada, MC Jordani, P Évora… - International journal of …, 2019 - mdpi.com
liver failure during the postoperative period after major liver resectionNO, natriuretic factors
and phosphodiesterase inhibitors, … anti-colorectal cancer drugs along the following pathways…

LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells

Q Li, Y Chen, D Zhao, S Yang, S Zhang, Z Wei… - Pharmacological …, 2019 - Elsevier
… -1 inhibitor (vorapaxar), phosphodiesterase III inhibitor (cilostazol) and the factor XA inhibitor
(… Mechanistically, it is found that NXT increases the catalytic activity of CYP2C19, which …

Sarcopenia in Bariatric Surgery-HIT BAR

A Finze - Obes Surg, 2021 - degruyter.com
… The phosphodiesterase-3 (PDE3)-inhibitor (cilostazol) has been associated … of cilostazol
on hepatocellular damage, liver regeneration, and inflammatory status after major hepatectomy