Redox proteomics and amyloid β‐peptide: insights into Alzheimer disease
DA Butterfield, D Boyd‐Kimball - Journal of neurochemistry, 2019 - Wiley Online Library
… synaptic plasticity and cell structure, neuroinflammation, impaired protein folding … Redox
proteomics analysis of carbonylated proteins in the hippocampus of 3-month-old 3xTg-AD mice …
proteomics analysis of carbonylated proteins in the hippocampus of 3-month-old 3xTg-AD mice …
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
ML Young, JL Franklin - Molecular and Cellular Neuroscience, 2019 - Elsevier
… 3xTg-AD mice as well as reduced brain oxidative stress, synapse loss, astrogliosis, microglial
cell … increasing cognitive impairment and dementia coincident with progressive damage to …
cell … increasing cognitive impairment and dementia coincident with progressive damage to …
Altered metabolism in Alzheimer disease brain: role of oxidative stress
NG Rummel, DA Butterfield - Antioxidants & Redox Signaling, 2022 - liebertpub.com
… plaques that are rich in amyloid β-peptide (Aβ), intraneuronal … type I protein that resides in
the plasma membrane. APP can be … Normal, mild cognitive impairment (MCI) and AD subjects …
the plasma membrane. APP can be … Normal, mild cognitive impairment (MCI) and AD subjects …
[HTML][HTML] Relationship between amyloid-β deposition and blood–brain barrier dysfunction in Alzheimer's disease
D Wang, F Chen, Z Han, Z Yin, X Ge… - Frontiers in Cellular …, 2021 - frontiersin.org
… neurotoxic effects that impair the blood–brain barrier (BBB). … Amyloid-β peptide fragments
vary in length from around 36 to … a variety of cell lines, including mouse Lewis lung carcinoma …
vary in length from around 36 to … a variety of cell lines, including mouse Lewis lung carcinoma …
[HTML][HTML] Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's disease …
… , partially improved clearance of amyloid β peptide only in the … in neuronal cell bodies and
plasma membrane where it co-… -α1/CPE on cognitive function of 3xTg AD mice in novel object …
plasma membrane where it co-… -α1/CPE on cognitive function of 3xTg AD mice in novel object …
Redox imbalance and metabolic defects in the context of Alzheimer disease
… cell vulnerability ultimately resulting in cognitive impairment. … of senile plaques, formed by
amyloid β-peptide (Aβ) and the … translocation to the plasma membrane regulating glucose …
amyloid β-peptide (Aβ) and the … translocation to the plasma membrane regulating glucose …
Β-amyloid and oxidative stress: Perspectives in drug development
G Caruso, SF Spampinato, V Cardaci… - Current …, 2019 - ingentaconnect.com
… APP and its proteolytic enzymes reach the cell membrane, where … , amyloid deposits,
gliosis, and memory impairment in the rat … Amyloid β-peptide (142)-induced oxidative stress in …
gliosis, and memory impairment in the rat … Amyloid β-peptide (142)-induced oxidative stress in …
[HTML][HTML] Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer's Disease Is Associated with Activation of HIF-1 …
S Petralla, L Saveleva, KM Kanninen, JS Oster… - Molecular …, 2024 - Springer
… and basal plasma membranes of the brain endothelial cells … of accumulated fibrillar and
amorphous amyloid-β peptide (Aβ) … including extensive amyloid pathology, cognitive impairment, …
amorphous amyloid-β peptide (Aβ) … including extensive amyloid pathology, cognitive impairment, …
Amyloid β peptide compromises neural stem cell fate by irreversibly disturbing mitochondrial oxidative state and blocking mitochondrial biogenesis and dynamics
MF Ribeiro, T Genebra, AC Rego… - Molecular …, 2019 - Springer
… Our results showed that Aβ impaired NSC viability and … consequent neuronal loss in
hippocampus and cortex [1, 2]. … networks responsible for mitochondrial redox homeostasis, …
hippocampus and cortex [1, 2]. … networks responsible for mitochondrial redox homeostasis, …
[HTML][HTML] Role of oxidative damage in alzheimer's disease and neurodegeneration: From pathogenic mechanisms to biomarker discovery
FR Buccellato, M D'Anca, C Fenoglio, E Scarpini… - Antioxidants, 2021 - mdpi.com
… Using redox proteomics to analyze the protein profile in brain … of AD by inducing various
protective genes in 3xTg-AD brain. … that females experience greater impairment of mitochondrial …
protective genes in 3xTg-AD brain. … that females experience greater impairment of mitochondrial …