[HTML][HTML] The role of the microbiota-gut-brain axis in the development of Alzheimer's disease

B Wiatrak, K Balon, P Jawień, D Bednarz… - International Journal of …, 2022 - mdpi.com
… ability to aggregate and integrate with cell membranes (Aβ, like LL-… Bonfili’s research group
treated 3xTg-AD mice for 4 months … responsible for memory impairment in mice suffering from …

[HTML][HTML] Revisiting the amyloid cascade hypothesis: from anti-Aβ therapeutics to auspicious new ways for Alzheimer's disease

MS Uddin, MT Kabir, MS Rahman, T Behl… - International journal of …, 2020 - mdpi.com
… for conversion from mild cognitive impairment (MCI) to AD … to the Golgi complex and the
cell membrane. This α-secretase … In the 3xTgAD mouse model, accumulation of CTF99 did not …

[HTML][HTML] Hypoxia and the kynurenine pathway: implications and therapeutic prospects in Alzheimer's disease

OS Adeyemi, OJ Awakan, LB Afolabi… - … Medicine and Cellular …, 2021 - hindawi.com
… tissues and localizes at the plasma membrane and organelles, such … elevation in QA was
also noticed in 3xTg-AD mice [82, 95]. … disease amyloidβ peptide and other amyloid proteins: a …

[HTML][HTML] Physical exercise and Alzheimer's disease: effects on pathophysiological molecular pathways of the disease

S López-Ortiz, J Pinto-Fraga, PL Valenzuela… - International Journal of …, 2021 - mdpi.com
impairment of brain Aβ clearance is assumed to arise [17]. … role in the structural integrity and
activity of cell membranes. … transmission and plasticity in 3xTg-AD mice that were exposed to …

[HTML][HTML] Tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic Alzheimer's disease (sAD) mouse model

V Latina, G Giacovazzo, P Calissano, A Atlante… - International Journal of …, 2021 - mdpi.com
Cerebral oxidative stress, mitochondrial impairment, synaptic … -STZ delivery produces brain
cerebral glucose deregulation … system [67], the levels of GSH/GSSG and the redox states of …

The chemokine-like receptor 1 deficiency improves cognitive deficits of AD mice and attenuates tau hyperphosphorylation via regulating tau seeding

H Zhang, A Lin, P Gong, Y Chen… - Journal of …, 2020 - Soc Neuroscience
… improved cognitive impairment of male and female amyloid β … and cerebral cortices of
the left hemisphere of the brain were … was expressed in the cell membrane, cytoplasm, and …

Effect of global brain ischemia on amyloid precursor protein metabolism and expression of amyloid-degrading enzymes in rat cortex: role in pathogenesis of …

E Babusikova, D Dobrota, AJ Turner… - Biochemistry (Moscow …, 2021 - Springer
… of two main protein clusters of amyloid β peptide (Aβ) (… number of amyloid plaques in the
brain of transgenic mice modelling … to impaired brain circulation and ischemic conditions in the …

FAD-deficient P187S mutation of NAD (P) H: quinone oxidoreductase 1 (NQO1* 2) binds and accelerates β-amyloid aggregation

S Panja, D Siegel, S Camandola, R de Cabo… - Bioscience …, 2022 - portlandpress.com
… vital component of the plasma membrane redox system (PMRS). … exhibited increased
resistance to amyloid-β peptide [14]. … and in the hippocampus and cerebral cortex of 3xTgAD mice

Hippocampal degeneration and behavioral impairment during Alzheimer-like pathogenesis involves glutamate excitotoxicity

OJ Olajide, IT Gbadamosi, EO Yawson… - Journal of Molecular …, 2021 - Springer
… An important underpinning of glutamate-dependent dysregulation of synaptic plasticity and
behavioral impairment in this study is by the alteration to cholinergic neurotransmitter system, …

Oxidative damage in neurodegeneration: Roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
… the abnormal deposition of amyloid β-peptide (Aβ) … redox proteomics analyses have
identified a significant number of HNE-modified brain proteins in AD and mild cognitive impairment