Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition

KLM Ooi, K Vacy, WC Boon - Neurochemistry International, 2021 - Elsevier
… metabolism in the brain leads to cognitive impairment, or if … of neural cell membranes.
Metabolically, fatty acids in the … due to increasing clearance of amyloid-β peptide, neurotrophic …

Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
cell death induced by glutamate in the hippocampal cell line … iron homeostasis is severely
disturbed in FPN-deficient mice. … redox carrier in the plasma membrane and Golgi apparatus …

Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology

K Sharma, S Pradhan, LK Duffy, S Yeasmin… - International Journal of …, 2021 - mdpi.com
… These receptors bind with G-proteins in the plasma membraneAmyloid-β peptide (Aβ), one
component of the extracellular … 3xTg-AD model mice experienced a reduction in both Aβ and …

Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders

SV Birajdar, F Mazahir, MI Alam, A Kumar… - European Journal of …, 2023 - Elsevier
… Aβ accumulation in the cerebral cortex of the brain which is a … changes in the brain, similarly,
the impairment in mitochondrial … The 3xTg-AD mice model demonstrated brain oxidative …

Contribution of hyperglycemia-induced changes in microglia to Alzheimer's disease pathology

M Hernández-Rodríguez, CF Clemente… - Pharmacological …, 2022 - Springer
… deposits composed mainly of amyloid-β peptide (Aβ) … several levels by binding to cell
membranes, receptors, and … In this sense, 3xTg-AD mice with hyperglycemia exhibited a …

Dynamic interplay between copper toxicity and mitochondrial dysfunction in alzheimer's Disease

G Tassone, A Kola, D Valensin, C Pozzi - Life, 2021 - mdpi.com
… specific brain areas such as the hippocampus, cerebral cortex, … Proteomics and redox
proteomics are powerful techniques … correlate well in 3xTg-AD mice with impaired spatial memory…

Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

HJ Lee, YH Jung, GE Choi, JS Kim, CW Chae… - Cell Death & …, 2021 - nature.com
impaired mitochondrial calcium efflux capacity in a 3xTg-AD … on STZ-induced cognitive
impairment, amyloidogenesis, Tau … the prefrontal cortex and hippocampus of mouse brain tissues. …

Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro

E Cuevas, H Rosas-Hernandez, SM Burks… - Metabolic brain …, 2019 - Springer
… The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding
with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated …

Oxidative stress in the pathogenesis of Alzheimer's disease and cerebrovascular disease with therapeutic implications

A Jurcau, A Simion - … (Formerly Current Drug Targets-CNS & …, 2020 - ingentaconnect.com
… Ca2+ entry through the plasma membrane and releases from the ER [70]. … 3xTg-AD mice. J
Neurosci 2009; 29(30): 9458-70. … Reactivity of apolipoprotein E4 and amyloid β peptide: lyso…

Probiotics for Alzheimer's disease: a systematic review

R Naomi, H Embong, F Othman, HF Ghazi, N Maruthey… - Nutrients, 2021 - mdpi.com
… This will initially evince as impaired hippocampal-… hippocampus and cerebral cortex. At
the same time, improvement in memory and spatial learning have been discovered in the mice […