Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport

M Oz, DE Lorke, FC Howarth - Medicinal Research Reviews, 2023 - Wiley Online Library
… a non-pungent TRPV1 agonist in DRG neurons. … Capsaicin (1–100 µM) Wistar rat trigeminal
ganglia and hippocampal pyramidal neurons/patch-clamp technique Direct inhibition of Ca 2

Discovery of nonpungent transient receptor potential vanilloid 1 (TRPV1) agonist as strong topical analgesic

J Ann, HS Kim, SA Thorat, H Kim, HJ Ha… - Journal of medicinal …, 2019 - ACS Publications
… the pattern of response. In our program to develop a nonpungent, highly efficacious TRPV1
agonist to avoid the adverse effects associated with the use of capsaicin, we investigated a …

[HTML][HTML] Co-application of eugenol and QX-314 elicits the prolonged blockade of voltage-gated sodium channels in nociceptive trigeminal ganglion neurons

SM Hwang, K Lee, ST Im, EJ Go, YH Kim, CK Park - Biomolecules, 2020 - mdpi.com
… -heat-sensitive transient receptor potential vanilloid 1 (TRPV1) … manner in capsaicin-sensitive
TG neurons. Eugenol also … using nonpungent agonists of TRPV1 other than capsaicin is …

The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin

M Alsalem, SA Aldossary, M Haddad, A Altarifi… - …, 2020 - journals.lww.com
… as capsaicin [ 2 , 3 ], as well as nonpungent capsaicin-… 2 (not B 1 ) receptors potentially
induce the synthesis of prostaglandins in adult rat trigeminal ganglia cultures and in isolated rat

[HTML][HTML] Endogenous and Exogenous Vanilloids Evoke Disparate TRPV1 Activation to Produce Distinct Neuronal Responses

R Kumar, M Geron, A Hazan, A Priel - Frontiers in Pharmacology, 2020 - frontiersin.org
… Here, we sought to describe the neuronal response of TRPV1… in rat trigeminal neurons
exposed to either capsaicin or … -diameter dissociated rat trigeminal ganglion (TG) neurons (P0) …

[HTML][HTML] Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions

YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
… , capsaicin, and related chemicals from the group of vanilloids as well as by noxious heat. As
such, it is mostly expressed in sensory neurons … ) and non-pungent (capsinoids) capsaicin-…

[HTML][HTML] Pungency perception and the interaction with basic taste sensations: an overview

W He, L Liang, Y Zhang - Foods, 2023 - mdpi.com
… transduced through transient receptor potential vanilloid 1 (TRPV1) … trigeminal nerve elicited
by substances, such as capsaicin, … The effect of salivary secretion in response to capsaicin

[HTML][HTML] Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain

V Arora, JN Campbell, MK Chung - Pharmacology & therapeutics, 2021 - Elsevier
Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is
… We will further classify defunctionalization into two types based on capsaicin dose, duration, …

[HTML][HTML] Interactions between chemesthesis and taste: role of TRPA1 and TRPV1

MR Rhyu, Y Kim, V Lyall - International journal of molecular sciences, 2021 - mdpi.com
… often co-expressed in trigeminal ganglion neurons, and are the most … The effects of capsaicin
are also mimicked by its non-pungentvanilloid 1 (TRPV1) monomer. The vanillyl moiety of …

Natural products and some semi-synthetic analogues as potential TRPV1 ligands for attenuating neuropathic pain

GG Naik, A Uniyal, D Chouhan… - Current …, 2022 - ingentaconnect.com
… [3H]-RTX binding sites, particularly in rat trigeminal ganglion, … of the responses mediated via
capsaicin in DRG neurons as well … of vanilloid agonists at the recombinant rat vanilloid VR1 …