[HTML][HTML] Cell-free DNA analysis in current cancer clinical trials: a review

M Cisneros-Villanueva, L Hidalgo-Pérez… - … journal of cancer, 2022 - nature.com
Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment
selection and clinical follow-up of cancer patients. Although its general methodological …

[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management

AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
… An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA)
as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

[HTML][HTML] Circulating cell-free DNA in breast cancer: Searching for hidden information towards precision medicine

M Panagopoulou, M Esteller, E Chatzaki - Cancers, 2021 - mdpi.com
… Our research focuses in the elucidation of the nature of circulating cell-free DNA (ccfDNA) …
Working on breast cancer, it became clear that although a promising biosource, its clinical …

Analysis of plasma cell-free DNA by ultradeep sequencing in patients with stages I to III colorectal cancer

T Reinert, TV Henriksen, E Christensen… - JAMA …, 2019 - jamanetwork.com
… Currently, decision making for ACT treatment is based on risk stratification by stage and
clinical risk factors. We found that in multivariate analysis ctDNA status (among stage, CEA, and …

Practical recommendations for using ctDNA in clinical decision making

SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
… data on the use of ctDNA in cancer patients is promising, it is … help guide clinical management
of cancer patients during the … for early cancer detection also examine cell-free DNA (cfDNA…

Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

P Song, LR Wu, YH Yan, JX Zhang, T Chu… - Nature biomedical …, 2022 - nature.com
… Dying cells release their DNA into blood plasma, where it is fragmented by nucleases into
cell-free DNA (cfDNA). cfDNA consists of short (≈160 nt) double-stranded DNA fragments that …

Cell-free DNA in cancer: current insights

H Fettke, EM Kwan, AA Azad - Cellular Oncology, 2019 - Springer
… an additional preservative to reduce cellular DNA release [68]. Comparative studies … cell-free
DNA™ tubes outperform conventional EDTA tubes at preventing significant genomic DNA

[HTML][HTML] Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer

D Fernandez-Garcia, A Hills, K Page… - … Cancer Research, 2019 - Springer
… more useful tests for monitoring treatment response and to inform clinical decision making.
The purpose of this study was to compare circulating cell-free DNA (cfDNA) and circulating …

Cellfree tumour DNA testing for early detection of cancer–a potential future tool

G Barbany, C Arthur, A Liedén… - Journal of Internal …, 2019 - Wiley Online Library
… introducing the concept of cell-free DNA (cfDNA) and … role in detecting early lesions and
distinguishing benign from malignant lesions. We will finally discuss its potential role in cancer

Use of circulating cell-free DNA to guide precision medicine in patients with colorectal cancer

VK Morris, JH Strickler - Annual Review of Medicine, 2021 - annualreviews.org
… The inability to identify risk of recurrence—beyond conventional surgical staging—complicates
adjuvant treatment decision making and potentially impairs patient survival. Some …