Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy

H Zhao, J Wei, J Sun - International Immunopharmacology, 2020 - Elsevier
… of TGF-β signaling in carcinomas and tumor microenvironment. … of TGF-β blockades used
or being evaluated in cancer therapy, … in the tumor which thrive in a TGF-β-rich environment. …

[HTML][HTML] TGF-β signaling: from tissue fibrosis to tumor microenvironment

JYF Chung, MKK Chan, JSF Li, ASW Chan… - International Journal of …, 2021 - mdpi.com
… In cancer, it plays a critical role in tumor microenvironment (TME) for accelerating … of TGF-β
signaling as a critical pathway for generating fibrotic TME, which contains numerous cancer-…

[HTML][HTML] TGFβ signaling in the pancreatic tumor microenvironment

DR Principe, KE Timbers, LG Atia, RM Koch, A Rana - Cancers, 2021 - mdpi.com
… features of PDAC pathobiology, and TGFβ inhibitors are beginning to show … roles of TGFβ
signaling in the pancreatic tumor microenvironment, as well as clinical trials evaluating TGFβ

[HTML][HTML] Integrin-mediated TGFβ activation modulates the tumour microenvironment

NF Brown, JF Marshall - Cancers, 2019 - mdpi.com
… Therefore, as certain integrins locally activate TGFβ, they are likely to have a role in the …
, we discussed the role of TGFβ in cancer, the role of integrins in activating TGFβ in the TME…

[HTML][HTML] Tumor microenvironment

B Arneth - Medicina, 2019 - mdpi.com
… of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in
… Aim: This study aims to explore the concept of the tumor microenvironment by conducting a …

[HTML][HTML] Transforming growth factor-β signaling pathway in colorectal cancer and its tumor microenvironment

Y Itatani, K Kawada, Y Sakai - International journal of molecular sciences, 2019 - mdpi.com
… insight into the important roles of TGF-β signaling in the tumor microenvironment. Here we
focus on the TGF-β signaling in CRC and its interaction with the tumor microenvironment. We …

Role of the tumor microenvironment in pancreatic cancer

T Murakami, Y Hiroshima, R Matsuyama… - Annals of …, 2019 - Wiley Online Library
… for pancreatic cancer. The present report reviews the pancreatic tumor microenvironment
from … A potential breakthrough therapy targeting the microenvironment is discussed. Figure 1 …

[HTML][HTML] Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment

BA Hanks, A Holtzhausen, KS Evans… - The Journal of …, 2020 - Am Soc Clin Investig
… As a result of soluble factors released by primary tumor tissues, APC … the tumor
microenvironment may be necessary for tumor progression (7), our understanding of both the tumor-…

[HTML][HTML] The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities

CM Neophytou, M Panagi, T Stylianopoulos… - Cancers, 2021 - mdpi.com
… blood microenvironment that facilitate their survival and transit. This review discusses the
roles of different cellular and structural tumor … , and miRNAs to inhibit tumor invasion as well as …

The role of MSCs in the tumor microenvironment and tumor progression

SY Ahn - Anticancer research, 2020 - ar.iiarjournals.org
… , which is associated with enhancement of the neoplastic properties of tumortumor cells
and MSCs in the tumor microenvironment is required. The Role of MSCs at the Primary Tumor