The adenosine A2A receptor antagonist SCH58261 reduces macrophage/microglia activation and protects against experimental autoimmune encephalomyelitis in …
Y Chen, ZX Zhang, LP Zheng, L Wang, YF Liu… - Neurochemistry …, 2019 - Elsevier
… -γ in the cerebral cortex, we examined … SCH58261 was effective during the neurological
deficit period of EAE, corresponding to the neuroinflammatory phase of MS, A 2A R antagonist …
deficit period of EAE, corresponding to the neuroinflammatory phase of MS, A 2A R antagonist …
[HTML][HTML] Selective adenosine A2A receptor inhibitor SCH58261 reduces oligodendrocyte loss upon brain injury in young rats
MA Al-Griw, RO Alghazeer, N Awayn… - Saudi Journal of …, 2021 - Elsevier
… Also, protection of developing OL precursors from damage might be a resultant of reduced
… that selective A 2A receptor inhibitor SCH58261 has significant protective roles upon brain …
… that selective A 2A receptor inhibitor SCH58261 has significant protective roles upon brain …
[HTML][HTML] Adenosine A2A receptor: a new neuroprotective target in light-induced retinal degeneration
M Soliño, IM Larrayoz, EM López… - Frontiers in …, 2022 - frontiersin.org
… A2A receptor agonist, or SCH 58261, an adenosine A2A … arguments in brain tissue questioning
the selectivity of CGS21680, … Finally, SCH 58261 also protected the retinal function, as all …
the selectivity of CGS21680, … Finally, SCH 58261 also protected the retinal function, as all …
Adenosine A2A receptor blockade attenuates excitotoxicity in rat striatal medium spiny neurons during an ischemic-like insult
E Coppi, F Cherchi, AJ Gibb - Neural Regeneration Research, 2023 - journals.lww.com
… A2A receptors are upregulated in the rat striatum after stroke and the selective antagonist
SCH58261 protects … medium spiny neurons in rat striatal brain slices exposed to oxygen and …
SCH58261 protects … medium spiny neurons in rat striatal brain slices exposed to oxygen and …
Adenosine A2A Receptor Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson's Disease
ACL Nunes, M Carmo, A Behrenswerth… - International journal of …, 2024 - mdpi.com
… A2AR are mostly synaptic receptors throughout the brain [25] … A2A adenosine receptor
antagonists protect the striatum … , EA Selective A2A receptor antagonist SCH 58261 modulates …
antagonists protect the striatum … , EA Selective A2A receptor antagonist SCH 58261 modulates …
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease
R Franco, R Rivas-Santisteban, M Casanovas, A Lillo… - Cells, 2020 - mdpi.com
… review entitled “Cerebral Protection by Adenosine” [9]. Based on data using brain ischemia-…
for one week with the A 2A R antagonist SCH-58261, a significant decrease in iNOS and a …
for one week with the A 2A R antagonist SCH-58261, a significant decrease in iNOS and a …
Time-dependent bidirectional neuroprotection by adenosine 2A receptor in experimental traumatic brain injury
P Velayutham, M Murthy, KS Babu - World Neurosurgery, 2019 - Elsevier
… failed to provide protection. In contrast, the direct injection of the A2A antagonist ZN 241385
… the TBI rats treated with A2AR agonist (CGS-21680) or A2AR antagonist (SCH-58261) at 15 …
… the TBI rats treated with A2AR agonist (CGS-21680) or A2AR antagonist (SCH-58261) at 15 …
Adenosine A2A receptor antagonist SCH58261 improves the cognitive function in Alzheimer's disease model mice through activation of Nrf2 via an autophagy …
Y Sun, C Liu, L He - Antioxidants and Redox Signaling, 2024 - liebertpub.com
… To determine the protection of SCH on synaptic function, we compared excitatory miniature
… responses essential for brain homeostasis, including blood-brain barrier maintenance, …
… responses essential for brain homeostasis, including blood-brain barrier maintenance, …
Blockade of adenosine A2A receptor alleviates cognitive dysfunction after chronic exposure to intermittent hypoxia in mice
XC Li, FF Hong, YJ Tu, YA Li, CY Ma, CY Yu… - … Neurology, 2022 - Elsevier
… brain and blockade of adenosine A2A receptors can reduce … or heterodimer form and
protects against cell apoptosis. To … if A 2A R agonist CGS21680, antagonist SCH58261, and A …
protects against cell apoptosis. To … if A 2A R agonist CGS21680, antagonist SCH58261, and A …
Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer's disease by promoting synaptic plasticity of …
Q Ji, Y Yang, Y Xiong, YJ Zhang, J Jiang… - Alzheimer's Research & …, 2023 - Springer
… Brains were cut into coronal sections at a thickness of 40 μm using a freezing microtome. …
In our present study, we found that the selective A 2A R antagonist SCH58261 can protect the …
In our present study, we found that the selective A 2A R antagonist SCH58261 can protect the …