… The ‘hourglass model’ structure was established as three-dimensional … The structure
showed that aquaporins contain tetrameric subunits placed in parallel, forming a fifth pore in the …

… In this chapter, we summarize the molecular aspects of aquaporins which include the
isoforms, crystal structure and the molecular mechanisms underlying the regulation of AQPs, with …

… More recent insights into aquaporin specificity are provided by the structure of AtTIP2;1,
which can transport ammonia [30]. Furthermore, AtPIP2;4 can transport hydrogen peroxide [29], …

… Our aim is to provide an overview of the mechanisms behind how aquaporin phosphorylation
controls cellular water balance and to identify key areas where further studies are needed. …

… Hence, as our analysis of the crystal structures does not match the results from MD … be due
to differences in the vicinal water dynamics impinging on the stabilizing H-bonds of His h1.-3 . …

… solutes across the cellular … However, the characteristics of prokaryotic aquaporins remain
largely unknown. We investigated the distribution and sequence characterization of aquaporins …

… the persistent idea that aquaporins are not druggable; the … no aquaporin-targeted drug in
the clinic and aquaporins have … routes to inhibition of aquaporin function have recently been …

… We use the term aquaporin for members of the MIP family, with the caveat that some do
not function as water channels and many others transport more than water. Nomenclature …

… Such aquaporins may be present in the whole plant or can be associated with different …
The present review addresses several aspects of plant aquaporins, from their structure, …

… Conflicting lines of evidence have been reported for the properties and gating of aquaporin
6 (AQP6). The human AQP6 coding sequence was first isolated from a kidney cDNA library, …