Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers

H Linke, B Höcker, K Furuta, NR Forde, PMG Curmi - Biophysical Reviews, 2020 - Springer
synthetic protein motors from the bottom up. Indeed, much effort has been invested in functional
protein … designing and building a functional synthetic protein motor has not been realized…

[图书][B] Artificial protein molecular motors and fluorescence enhancement in nanowires for biosensing

I Unksov - 2023 - portal.research.lu.se
… Another design, the Tumbleweed, is a single-molecule protein motor synthesised to bind to
… movements of fluorescent molecular motors such as TWs that would move towards or from a …

The Lawnmower: an autonomous, protein-based artificial molecular motor

CS Korosec, I Unksov, P Surendiran, R Lyttleton… - arXiv preprint arXiv …, 2021 - arxiv.org
towards nanotechnology applications of artificial protein … nonmotor proteins as building
blocks to engineer novel motors (… , motility of a synthetic motor constructed of proteins – the …

[HTML][HTML] Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle

CS Korosec, IN Unksov, P Surendiran… - Nature …, 2024 - nature.com
… Our work opens an avenue towards nanotechnology applications of artificial protein … of
synthetic biology. Here, we demonstrate biased motion of a protein-based synthetic motor dubbed …

Synthetic systems powered by biological molecular motors

G Saper, H Hess - Chemical reviews, 2019 - ACS Publications
… After briefly introducing the motor proteins kinesin and myosin and their associated … be
used to tether the motor to a surface or artificial cargo. The heads walk toward the plus end of a …

The bar-hinge motor: a synthetic protein design exploiting conformational switching to achieve directional motility

LSR Small, MJ Zuckermann, RB Sessions… - New Journal of …, 2019 - iopscience.iop.org
… This track can be synthesized from DNA using the same methods as for the Tumbleweed
motor … are key steps toward delivering the first autonomously walking designed protein motor. …

[PDF][PDF] Investigation of neurotoxic principles of the Tumbleweed, Trachyandra Laxa, responsible for livestock losses in Southern Africa

HM Van Wyk - 2020 - repository.unam.edu.na
… laxa (Tumbleweed). Thus far no therapeutic measures have been developed for the … A
preventative agent for tumbleweed poisoning of eg sheep could potentially be found. This will …

Methods for performance characterization of artificial molecular motors

I Unksov - 2021 - portal.research.lu.se
protein motor we study, the Tumbleweed (TW) (Figure 1b), a construct synthetized de novo
from DNA-binding protein … Because of that, the motor tends towards previously unexplored …

[HTML][HTML] Classical and emerging regulatory mechanisms of cytokinesis in animal cells

V Verma, A Mogilner, TJ Maresca - Biology, 2019 - mdpi.com
… to serve as tracks for the motor protein MKLP1 to deliver a positive … To investigate the
function of Tumbleweed, this study … toward the cell poles; 2) stabilization of astral MTs aimed …

[HTML][HTML] Collective Molecular Machines: Multidimensionality and Reconfigurability

B Wang, Y Lu - Nano-Micro Letters, 2024 - Springer
… therefore also been used as important motor modules in artificial molecular machines [22,…
artificial motors based on proteins. For example, a synthetic protein motor called "tumbleweed" …