[HTML][HTML] Out of control: the role of the ubiquitin proteasome system in skeletal muscle during inflammation

S Haberecht-Müller, E Krüger, J Fielitz - Biomolecules, 2021 - mdpi.com
… and coordinated process comprising many different pathways, … related members, including
NF-κB1 (also named p50), NF-κB2 … of the p105 and p100 precursor proteins, respectively [310,…

[HTML][HTML] Small molecule NF-κB pathway inhibitors in clinic

V Ramadass, T Vaiyapuri, V Tergaonkar - International journal of …, 2020 - mdpi.com
… , the pathway mediated by NF-κB1/… proteins need not be ubiquitinated before degradation
like conversion of p105 to p50 in canonical NF-κB pathway or in post-translational processing. …

Ubiquitination in rheumatoid arthritis

T Behl, S Chadha, M Sachdeva, A Kumar, A Hafeez… - Life Sciences, 2020 - Elsevier
… The lysosomal pathway is involved in degradation process of … proteins which are required
for proteasomal degradation … is a 26-kDa active precursor protein) and carried out by metallo-…

[HTML][HTML] Ubiquitination in the regulation of inflammatory cell death and cancer

PE Cockram, M Kist, S Prakash, SH Chen… - Cell Death & …, 2021 - nature.com
system that regulate fundamental cellular processes … drugs (iMiDs) in the ubiquitin proteasome
system (UPS), and the … repeats-containing proteins), while NF-κB1 is partially degraded, …

Investigating NF-κB ubiquitination: An in vitro study

JP Mitchell - 2019 - theses.gla.ac.uk
… the components of the ubiquitin-proteasome system (UPS) … many of which have essential
roles in the immune system, which … protein, and it controls a diverse array of cellular processes (…

[HTML][HTML] Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome …

M Pakjoo, SE Ahmadi, M Zahedi, N Jaafari… - Cell Communication and …, 2024 - Springer
… The ubiquitin-proteasome system (UPS) plays a crucial role … Furthermore, the conversion
of p50 from its precursor protein … of the RelA(p65)/NF-κB1(p50) heterodimer. Another non-…

[HTML][HTML] The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm …

J Kamińska, M Tylicka, K Sutkowska, KM Gacuta… - Scientific Reports, 2024 - nature.com
… of NF-κB1 (p105) and NF-κB p65 precursor proteins and … on our results, indicating a
required sample size of 19 for … , which is processed to generate the mature protein. Moorthy …

[HTML][HTML] The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma

D Vrábel, L Pour, S Ševčíková - Blood reviews, 2019 - Elsevier
… They are NF-κB1 (p50 and its precursor p105), NF-κB2 (p52 … of C-terminal part of precursor
protein p100; Ub – ubiquitin, P … is represented by the ubiquitin-proteasome pathway. Hence, …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
… genes encoding proteins having a vital role in processes of … is involved in the ubiquitin-proteasome
system [127, 128]. … or beta–site amyloid precursor protein cleaving enzyme 1 (BACE1…

[HTML][HTML] NF-κB: at the borders of autoimmunity and inflammation

L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
… An essential regulatory process that controls autoreactive T-cells is mediated by the … The
ubiquitin-proteasome system plays an important role in enabling activation of NF-κB. The use of …