Molecular bases of VEGFR-2-mediated physiological function and pathological role

X Wang, AM Bove, G Simone, B Ma - … in Cell and Developmental …, 2020 - frontiersin.org
… VEGFR-2 Structural Characteristics and Function Vascular endothelial growth factors are
main regulators in vasculogenesis and angiogenesis and play their roles by binding to …

Vascular endothelial growth factor biology for regenerative angiogenesis

A Uccelli, T Wolff, P Valente, N Di Maggio… - Swiss medical …, 2019 - smw.ch
… -D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol. 2008;…
vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological

Role of vascular endothelial growth factor (VEGF) in human embryo implantation: clinical implications

X Guo, H Yi, TC Li, Y Wang, H Wang, X Chen - Biomolecules, 2021 - mdpi.com
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical
role in various physiological … and function of VEGF in the reproductive system around the …

Structural basis for vascular endothelial growth factor receptor activation and implications for disease therapy

F Shaik, GA Cuthbert, S Homer-Vanniasinkam… - Biomolecules, 2020 - mdpi.com
… VEGFR1 and VEGFR2 play important roles in physiological and pathological angiogenesis,
whereas VEGFR3 is mainly involved in lymphangiogenesis [9,10]. This review focuses on …

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
vasculature is called angiogenesis. It is an essential physiological process for the growth
of cells, tissue repair, wound healing, and reproductive system of females. The process of …

Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy

SA Patel, MB Nilsson, X Le, T Cascone, RK Jain… - Clinical Cancer …, 2023 - AACR
factors such as VEGF-A, basic fibroblast growth factors (bFGF), … variety of cells in both
physiologic and pathologic settings. The … localized on blood vascular endothelial cells. VEGFR2 is …

VEGF in signaling and disease: beyond discovery and development

RS Apte, DS Chen, N Ferrara - Cell, 2019 - cell.com
… discovery of vascular endothelial-derived growth factor (VEGF) … during development and
physiological homeostasis. Over a short … The role of vascular endothelial growth factor in ocular …

Endothelial cells regulate physiological cardiomyocyte growth via VEGFR2-mediated paracrine signaling

R Kivelä, KA Hemanthakumar, K Vaparanta… - Circulation, 2019 - Am Heart Assoc
… We demonstrate that the endothelial cell vascular endothelial growth factor receptor 2-Notch …
coordinate cardiac hypertrophy and angiogenesis during physiological myocardial growth. …

Molecular mechanism of VEGF and its role in pathological angiogenesis

A Ahmad, MI Nawaz - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
… of vascular endothelial-derived growth factor (VEGF) in the … the quest to investigate the role
of VEGF in physiological and … targeting human vascular endothelial growth factor receptor-2 …

Tumor angiogenesis and VEGFR-2: mechanism, pathways and current biological therapeutic interventions

AA Shah, MA Kamal, S Akhtar - Current Drug Metabolism, 2021 - ingentaconnect.com
factor (signaling molecule) is the VEGF/VPF that plays a specific role in the process of
angiogenesis both in physiological … structure of vascular endothelial growth factor receptor 2 (…