Role of membrane environment and membrane-spanning protein regions in assembly and function of the Class II Major Histocompatibility complex

AM Dixon, S Roy - Human Immunology, 2019 - Elsevier
Class II Major Histocompatibility complex (MHC-II) is a … , the structural determinants of
MHC-II function have been of great interest for the past 30 years, resulting in a robust structural

Clustering of major histocompatibility complex-class I molecules in healthy and cancer colon cells revealed from their nanomechanical properties

M Moretti, R La Rocca, M Perrone Donnorso, B Torre… - ACS …, 2021 - ACS Publications
Three-dimensional plotting and morphological data analysis were performed with the
free software Gwyddion. The histogram of the cell height data was obtained directly from the …

The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages

F Mompart, A Kamgoué, Y Lahbib-Mansais… - BMC Molecular and Cell …, 2021 - Springer
class I, III and II) in macrophages using 3D-FISH. Since this complex presents major differences
in humans … presence of the centromere between class III and class II regions in pigs, the …

Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen

NK Singh, ET Abualrous, CM Ayres… - Proteins: Structure …, 2020 - Wiley Online Library
… TCRs bind class I and class II peptide/MHC complexes, which we … and presented by major
histocompatibility complex (MHC) … from three-dimensional coordinates are shown in Figure 2. …

[HTML][HTML] Extracellular crosslinking mass spectrometry reveals HLA class I–HLA class II interactions on the cell surface

G Armony, AJR Heck, W Wu - Molecular Immunology, 2021 - Elsevier
… the three-dimensional protein structures. As such, summarizing these restraints into possible
modes of interaction would be critical for structural modeling of these complexes. To this …

Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides

A Strand, ST Shen, DR Tomchick, J Wang… - … Structure and …, 2022 - Taylor & Francis
Three-dimensional structures of the four heptapeptide ND1-M3 complexes were determined
by X-ray crystallography. Protein expression, purification and crystallization methods, as …

The major histocompatibility complex

DS Monos, RJ Winchester - Clinical Immunology, 2019 - Elsevier
… The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general … a
peculiar three-dimensional shape that has been preserved on both class I and class II molecules

pHLA3D: updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules

DMT e Oliveira, MSC Marroquim… - Human Immunology, 2021 - Elsevier
… of three-dimensional (3D) structures of HLA molecules, we … published 106 3D structures of
HLA class I molecules from the … more 127 3D structures of HLA class II molecules (41 DR, 42 …

Major histocompatibility complex antigens

PR Hess - Schalm's Veterinary Hematology, 2022 - Wiley Online Library
… Despite these interspecies genetic differences in the MHC, the three-dimensional structures
of MHC class I and class II molecules are well-conserved between species, reflecting a …

Peptide–MHC binding reveals conserved allosteric sites in MHC class I-and class II-restricted T cell receptors (TCRs)

Y He, P Agnihotri, S Rangarajan, Y Chen… - Journal of molecular …, 2020 - Elsevier
… The complete three-dimensional structure of the TCRαβ/CD3εγ/CD3εδ/CD3ζζ complex was
… fragments presented by major histocompatibility complex (MHC) molecules on antigen-…