[HTML][HTML] MatchTope: A tool to predict the cross reactivity of peptides complexed with Major Histocompatibility Complex I

…, P Vianna, MV de Freitas, I Pöhner… - Frontiers in …, 2022 - frontiersin.org
… sequences binding to the Major Histocompatibility Complex (pMHC). However, few of
these bioinformatics tools take into account the pMHC three-dimensional structure. Here, we …

Hydrophobic core evolution of major histocompatibility complex class I chain-related protein a for dramatic enhancing binding affinity

W Cai, S Peng, Y Tian, Y Bao, Q Liu, Y Dong… - International Journal of …, 2024 - Elsevier
… cell stress molecule, major histocompatibility complex class I … killer group 2D (NKG2D)
homodimer to form three molecule … Crystal structures of the NKG2D–MICA variant complexes

[HTML][HTML] The ABC of major histocompatibility complexes and T cell receptors in health and disease

K Kedzierska, M Koutsakos - Viral Immunology, 2020 - liebertpub.com
… While antibodies bind to three-dimensional epitopes on … glycoprotein called major
histocompatibility complexes (MHCs) (… -encoded antigen-presenting molecules and foreign …

Major Histocompatibility Complex and Antigen Presentation

S Beri, N Garg - An Interplay of Cellular and Molecular …, 2022 - taylorfrancis.com
… FIGURE 7.7 (A) The three dimensional protein structure of Class I MHC molecule. (b) The
antigen binding site of Class I MHC molecule with the antigen is highlighted in yellow. …

Four Faces of cell-surface HLA Class-I: Their antigenic and immunogenic divergence generating novel targets for Vaccines

MH Ravindranath, NM Ravindranath, SR Selvan… - Vaccines, 2022 - mdpi.com
… with the three-dimensional structure of a peptide carried on an HLA class-I or -II molecule. …
The HLA-II β chain of Face-1 contains only an N-linked, complex-type carbohydrates chain. …

Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules

JM Dijkstra, T Yamaguchi - Immunogenetics, 2019 - Springer
… Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and
not in … MHC class II type structures likely represent the ancestral structure of MHC molecules. …

Combining three-dimensional modeling with artificial intelligence to increase specificity and precision in peptide–MHC binding predictions

MP Aranha, YSM Jewel, RA Beckman… - The Journal of …, 2020 - journals.aai.org
… into the four binding classes based on their experimental binding affinities (ie… class, we
aligned the structures of all the p–MHC complexes in each class to the reference crystal structure

Molecular histocompatibility beyond tears: The next generation version

N Saleem, R Das, AR Tambur - Human Immunology, 2022 - Elsevier
… HLA typing by molecular sequencing techniques revolutionized our understanding of the …
molecules at the population level. Together with deciphering the three-dimensional structure, it …

Selective Inhibitors of T Cell Receptor Recognition of Antigen–MHC Complexes for Rheumatoid Arthritis

F Ria, D Pirolli, G Di Sante, B Righino… - ACS medicinal …, 2019 - ACS Publications
… major histocompatibility complex (MHC) of class II in complex … previously reported three-dimensional
model structure of the … recognition of antigen-HLA complex in RA were identified by …

Deep neural networks predict class I major histocompatibility complex epitope presentation and transfer learn neoepitope immunogenicity

BA Albert, Y Yang, XM Shao, D Singh… - Nature machine …, 2023 - nature.com
three-dimensional structure of an MHC molecule of interest. The mean attention for each
pseudosequence position per allele in the EL evaluation dataset is illustrated in Extended Data …