Transcriptional regulation in non-alcoholic fatty liver disease

S Steensels, J Qiao, BA Ersoy - Metabolites, 2020 - mdpi.com
… Regardless of the source of the hit (s), hepatic responses to extrahepatic stimuli are controlled
by well-described transcriptionally regulated pathways that help transcribe the relevant …

Epigenetic regulation of hepatic lipogenesis: Role in hepatosteatosis and diabetes

J Viscarra, HS Sul - Diabetes, 2020 - Am Diabetes Assoc
… LXRs are responsive to both insulin and metabolites and function in the transcriptional
regulation of lipogenesis. LXR forms heterodimers with retinoid X receptor (RXR) and binds to …

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

L Bideyan, W Fan… - Proceedings of the …, 2022 - National Acad Sciences
… accessibility, gene expression, and transcription factor binding. We reveal distinct mechanisms
of LXR transcriptional regulation of both metabolic and nonmetabolic genes in liver. We …

[HTML][HTML] Unraveling the regulation of hepatic gluconeogenesis

X Zhang, S Yang, J Chen, Z Su - Frontiers in endocrinology, 2019 - frontiersin.org
… We review here the molecular mechanisms underlying the transcriptional regulation of
gluconeogenesis in response to nutritional and hormonal changes. The nutrient state determines …

Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors

A Cui, D Ding, Y Li - Diabetes, 2021 - Am Diabetes Assoc
transcriptional regulator and plays roles in hepatic glucose metabolism (29). The proteolytic
cleavage and acetylation modification of CREBH are regulated by … to control hepatic glucose …

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

L Hodson, PJ Gunn - Nature Reviews Endocrinology, 2019 - nature.com
Regulation of DNL occurs via transcriptional regulation of ACC and FAS, primarily by sterol
regulatory element-binding protein 1c (SREBP1c) and carbohydrate-responsive element-…

[HTML][HTML] Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

Y Xiao, M Kim, MA Lazar - Molecular Metabolism, 2021 - Elsevier
transcriptional regulation. The fourth group is composed of orphan receptors whose
endogenous ligands remain uncertain, including estrogen-related receptor (ERR), constitutive …

[HTML][HTML] Regulation of hepatic autophagy by stress-sensing transcription factor CREBH

H Kim, D Williams, Y Qiu, Z Song, Z Yang… - The FASEB …, 2019 - ncbi.nlm.nih.gov
… In summary, we identified CREBH as a key transcriptional regulator of hepatic autophagy
and lysosomal biogenesis for the purpose of maintaining hepatic lipid homeostasis under …

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Y Han, Z Hu, A Cui, Z Liu, F Ma, Y Xue, Y Liu… - Nature …, 2019 - nature.com
… This report demonstrates that Insig may act as a novel substrate for AMPK in regulating
hepatic lipogenesis and maintaining lipid metabolism through a post-translational modification. …

A cellular perspective of adipogenesis transcriptional regulation

W Kuri‐Harcuch, C Velez‐delValle… - Journal of cellular …, 2019 - Wiley Online Library
… data described on transcription factors that regulate adipose differentiation, outside of those
that were reported earlier as part of the canonical adipogenic transcriptional cascade, which …